Leukemia Clinical Trial
Official title:
Pharmacogenetics of Gemtuzumab Ozogamicin (GO) Therapy in Acute Myeloid Leukemia
RATIONALE: DNA analysis of blood and tissue samples may help doctors predict how well
patients will respond to treatment. It may also help doctors learn more about how gemtuzumab
ozogamicin works in the body.
PURPOSE: This research study is looking at gemtuzumab ozogamicin in DNA samples from
patients with acute myeloid leukemia treated on COG-AAML0531.
OBJECTIVES:
- To genotype the genomic DNA from acute myeloid leukemia (AML) patients treated on
COG-AAML0531 clinical trial for CD33 (and PgP and SOC3) single nucleotide polymorphisms
(SNPs).
OUTLINE: Archived DNA samples are analyzed for single nucleotide polymorphisms in CD33, PgP,
and SOC3 genes by Sequenome platform. Results are then compared with patients clinical
outcomes, including minimal-residual disease levels post induction I (chemotherapy and
gemtuzumab ozogamicin), complete remission rates, refractory disease with various levels of
bone marrow blasts, development of CNS/persistent disease, event-free survival, overall
survival, and toxicity.
;
Observational Model: Case-Only, Time Perspective: Retrospective
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