Leukemia Clinical Trial
Official title:
A Randomized Phase III Study of Intensive Consolidation With High Dose Cytosine Arabinoside in Acute Myelogenous Leukemia (AML-8B)
RATIONALE: Patient abstract not available
PURPOSE: Patient abstract not available
Status | Completed |
Enrollment | 160 |
Est. completion date | |
Est. primary completion date | June 1994 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 45 Years to 60 Years |
Eligibility |
DISEASE CHARACTERISTICS: Newly diagnosed, untreated acute myelogenous leukemia (AML), as
follows: Any cytological type according to the FAB classification At least 30% blast cells
in bone marrow smear required Secondary acute leukemia eligible, i.e.: AML cured Hodgkin's
disease or other malignancy AML following exposure to alkylating agents or radiation The
following are specifically excluded: Blast crisis of chronic myeloid leukemia Leukemia
supervening after other myeloproliferative disease Leukemia supervening after overt
myelodysplastic disorder (e.g., refractory anemia with excess blasts) of more than 6
months' duration PATIENT CHARACTERISTICS: Age: 45-60 Patients 10-45 are eligible for EORTC-06863 Performance status: Not specified Hematopoietic: Not specified Hepatic: No severe concomitant hepatic disease Renal: No severe concomitant renal disease Cardiovascular: No severe concomitant cardiac disease Other: No severe concomitant neurological disease No other progressive malignant disease PRIOR CONCURRENT THERAPY: Biologic therapy: No prior therapy Chemotherapy: No prior chemotherapy Endocrine therapy: No more than 7 days of corticosteroids for AML Radiotherapy: No prior radiotherapy Surgery: Not applicable |
Allocation: Randomized, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
European Organisation for Research and Treatment of Cancer - EORTC |
Zittoun R, Suciu S, Mandelli F, de Witte T, Thaler J, Stryckmans P, Hayat M, Peetermans M, Cadiou M, Solbu G, Petti MC, Willemze R. Granulocyte-macrophage colony-stimulating factor associated with induction treatment of acute myelogenous leukemia: a rando — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Disease-free survival and overall survival in patients who achieve complete remission after induction | No | ||
Primary | Toxicity | Yes | ||
Primary | Quality of life | No | ||
Primary | Improved therapeutic results as measured by activation of leukemic cells into the cell cycle and/or acceleration of hematopoietic recovery | No | ||
Primary | Relative efficacy of autologous bone marrow therapy | No |
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