Leukemia Clinical Trial
Official title:
MLL Rearrangements in Acute Myeloid Leukemia: A Pilot Project to Expand and Study MLL-ENL in NOD SCID Gamma Mice
RATIONALE: Studying samples of bone marrow from patients with cancer in the laboratory may
help doctors learn more about changes that occur in DNA and identify biomarkers related to
cancer.
PURPOSE: This research study is looking at bone marrow samples from patients with acute
myeloid leukemia.
OBJECTIVES:
- To successfully transplant human acute myeloid leukemia (AML) cells into
immunocompromised mice for the purpose of expansion of the cells.
- To harvest the cells and use chromatin immunoprecipitation (ChIP) methods to identify
the locations of the protein complexes on the genome.
- To study the interactions of the Super Elongation Complex (SEC) and Dot1 Complex
(DotCom) complexes in human leukemia samples.
- To compare the genomic targets of the complexes formed by MLL-ENL chimeras to
non-MLL-rearranged leukemia samples to normal controls.
OUTLINE: Cryopreserved cells are implanted into NOD SCID gamma mice, expanded, harvested,
and studied by chromatin immunoprecipitation (ChIP) methods (using antibodies to ENL, Af9,
and AF10). Results are then analyzed by PCR, DNA sequencing, and/or microarray analysis.
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Observational Model: Cohort, Time Perspective: Prospective
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