Leukemia Clinical Trial
Official title:
Telomere Length and Telomerase Mutations in Pediatric Acute Myeloid Leukemia
RATIONALE: Studying bone marrow samples from patients with cancer in the laboratory may help
doctors learn more about changes that occur in DNA and identify biomarkers related to
cancer.
PURPOSE: This research study is studying biomarkers in samples from young patients with
acute myeloid leukemia.
OBJECTIVES:
- To compare the frequency of germline telomerase mutations in pediatric patients with
acute myeloid leukemia (AML) demonstrating prolonged myelosuppression, defined as ≥ 1
episode > 35 days of neutrophil count recovery after chemotherapy, to the pediatric
patients with the expected myelosuppression, defined as consistently < 35 days of
neutrophil count recovery after chemotherapy.
- To assess association between telomerase mutations and incidence of grade 3 or 4
mucositis, relapse, and death.
- To compare germline (remission) telomere length in pediatric AML patients demonstrating
delayed bone marrow recovery with the pediatric patients with consistently expected
recovery.
- To assess whether a correlation between telomere length and incidence of grade 3 or 4
mucositis, relapse, and death exist.
OUTLINE: This is a multicenter study.
Cryopreserved bone marrow samples are analyzed for DNA sequencing and mutation by
Sanger-based sequencing methods, quantitative PCR, and SeqMan Pro (Lasergene from DNAStar).
Results are then compared with previously published data and existing databases to determine
the allele frequency in control populations.
;
Observational Model: Case-Only, Time Perspective: Retrospective
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