Leukemia Clinical Trial
Official title:
Genome Wide Association Study Evaluating Genetic Factors Related to the Efficacy and Tolerability of Fludarabine Treatment in Patients With CLL
RATIONALE: Studying samples of DNA in the laboratory from patients who received
fludarabine-based treatment may help doctors learn more about the effects of fludarabine on
cells. It may also help doctors understand how well patients respond to treatment.
PURPOSE: This research study is studying DNA samples from patients with chronic lymphocytic
leukemia previously treated with fludarabine-based therapy.
OBJECTIVES:
- To identify genetic characteristics associated with the efficacy and toxicity of
fludarabine-based treatment in patients with chronic lymphocytic leukemia who
participated on E2997.
- To validate these genetic characteristics with a cancer cell model system to confirm
association and dissect the mechanism of effect.
OUTLINE: Archived DNA samples are analyzed for genetic characteristics associated with the
efficacy and toxicity to fludarabine-based treatment using Affymetrix 6.0 single nucleotide
polymorphism arrays. The results are then compared with data of genes identified in a cancer
cell model system, and with clinical data (response, toxicity, overall survival, and
progression-free survival) associated with each patient sample.
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