Leukemia Clinical Trial
Official title:
Identifying Rare Genetic Variants Involved in High Risk Acute Lymphoblastic Leukemia (ALL) Via Pooled DNA Sequencing
Verified date | July 2016 |
Source | Children's Oncology Group |
Contact | n/a |
Is FDA regulated | No |
Health authority | United States: Federal Government |
Study type | Observational |
RATIONALE: Studying samples of blood or tumor tissue from patients with cancer in the
laboratory may help doctors learn more about changes that occur in DNA and identify
biomarkers related to cancer.
PURPOSE: This research study is studying biomarkers in DNA samples from patients with newly
diagnosed high-risk acute lymphoblastic leukemia.
Status | Completed |
Enrollment | 350 |
Est. completion date | |
Est. primary completion date | December 2015 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 1 Year to 30 Years |
Eligibility |
DISEASE CHARACTERISTICS: - Newly diagnosed with high-risk B-precursor acute lymphoblastic leukemia - Matched patients non-tumor and blast DNA samples - Enrolled on COG-P9906 or COG-AALL0232 protocols - Cohort of random pediatric DNA samples extracted from newborn infants' blood spots from the State of Missouri PATIENT CHARACTERISTICS: - Newborn infants from the state of Missouri PRIOR CONCURRENT THERAPY: - Not specified |
Observational Model: Case-Only, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Children's Oncology Group | National Cancer Institute (NCI) |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Identification of loci enriched for genetic variation suggestive of pre-B leukemogenesis | No | ||
Primary | Correlation between high-risk acute lymphoblastic leukemia with clinical phenotypes, co-morbidities, toxicities, outcomes to the genes or pathways found to harbor a significant increase in genetic variation | No |
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