Leukemia Clinical Trial
Official title:
Genome-Wide Interrogations in Childhood Acute Lymphoblastic Leukemia (ALL)
Verified date | May 2016 |
Source | Children's Oncology Group |
Contact | n/a |
Is FDA regulated | No |
Health authority | United States: Federal Government |
Study type | Observational |
RATIONALE: Studying samples of blood and bone marrow from patients with cancer in the
laboratory may help doctors learn more about changes that occur in DNA and identify
biomarkers related to cancer. It may also help doctors predict how well patients will
respond to treatment.
PURPOSE: This research study is looking at DNA in blood and bone marrow samples from young
patients with acute lymphoblastic leukemia.
Status | Completed |
Enrollment | 1000 |
Est. completion date | May 2016 |
Est. primary completion date | May 2016 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 1 Year to 30 Years |
Eligibility |
DISEASE CHARACTERISTICS: - Diagnosis of acute lymphoblastic leukemia (ALL) - Previously enrolled in COG-9900, COG-C1991, COG-AALL03B1, COG-AALL05B1, COG-AALL08P1, or other current COG or legacy trials for ALL AND consented to submit blood and marrow samples for biological research studies - Meets = 1 of the following criteria: - Germline DNA that has been extracted from blood (preferentially) or bone marrow (if no appropriate blood available) that was collected on or after Day 28 of remission indication therapy, or is known to come from a sample that contained < 10% leukemic blasts - ALL blast DNA that has been extracted from bone marrow (preferentially) or blood (if from a sample that contained > 90% leukemic blasts and no diagnostic bone marrow is available) that was collected at the time of ALL diagnosis PATIENT CHARACTERISTICS: - Not specified PRIOR CONCURRENT THERAPY: - See Disease Characteristics |
Observational Model: Case-Only, Time Perspective: Retrospective
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Children's Oncology Group | National Cancer Institute (NCI) |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Determination of genome-wide genotypes | No | ||
Primary | Mechanism for storing, distributing, and tracking usage of blast and germline genomic information | No | ||
Primary | Identification of genetic variations associated with important phenotypes (treatment response, adverse effects, risk of acute lymphoblastic leukemia [ALL], and risk of ALL subtypes) | No | ||
Primary | Data resource, that can be linked with additional tumor cell information, to better characterize the biology and subtypes of childhood ALL | No |
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