Leukemia Clinical Trial
Official title:
Molecular and Functional Characterisation of Bone Marrow Function in Normal Subjects, Myelodysplastic Syndromes (MDS) and Secondary Disorders of Heamatopoiesis
RATIONALE: Studying samples of blood and bone marrow in the laboratory from patients at risk
of developing myelodysplastic syndrome may help doctors learn more about changes that occur
in DNA and identify biomarkers related to disorders of the blood and bone marrow.
PURPOSE: This research study is looking at biomarkers in patients at risk of developing
myelodysplastic syndrome or other disorders and in healthy participants.
OBJECTIVES:
Primary
- To identify novel biomarkers of disease that would help in the initial diagnosis of
myelodysplastic syndromes (MDS).
Secondary
- To understand the genesis of anemia in cancers.
- To identify novel biomarkers of disease that predict progression of MDS to acute
myeloid leukemia.
OUTLINE: Blood and bone marrow samples are collected. Hemopoietic stem cells (HSC) and
progenitor cells are isolated from samples for analysis. Some of these HSC and progenitor
cells are used for functional assays. From the rest of the cells, DNA, RNA, and protein is
extracted for molecular analyses, including gene mutation analysis, gene methylation assays,
chromatin immunoprecipitation, microarray, and real-time polymerase chain reaction.
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N/A
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