Leukemia Clinical Trial
Official title:
Posttransplant Immunotherapy With Donor Lymphocyte Infusions and Autologous Tumor Vaccines After HLA-Matched Transplant
RATIONALE: Vaccines made from the patient's cancer cells may help the body build an
effective immune response to kill cancer cells. Giving vaccine therapy together with donor
lymphocyte infusion after a stem cell transplant from the patient's brother or sister may
kill any cancer cells that remain after transplant.
PURPOSE: This clinical trial is studying the side effects, best dose, and how well vaccine
therapy with or without donor lymphocyte infusion works in treating patients with acute
myeloid leukemia, acute lymphoblastic leukemia, or multiple myeloma undergoing donor stem
cell transplant.
OBJECTIVES:
- Determine time to relapse and overall survival of patients with high-risk acute myeloid
leukemia, acute lymphoblastic leukemia, or multiple myeloma treated with autologous
tumor cell vaccine with or without donor lymphocyte infusion after HLA-matched related
sibling nonmyeloablative hematopoietic stem cell transplantation.
- Evaluate the safety and tolerability of this regimen in these patients.
- Determine the maximum tolerated dose of donor lymphocyte infusions in these patients.
OUTLINE: Patients undergo collection of tumor cells for production of the cancer cell
vaccine and then undergo HLA-matched related sibling nonmyeloablative hematopoietic stem
cell transplantation (HSCT). Patients then receive cancer cell vaccine with or without donor
lymphocyte infusion. The donor lymphocytes are obtained from the same relative who donated
stem cells for the HSCT.
PROJECTED ACCRUAL: A total of 30 patients will be accrued for this study.
;
Masking: Open Label, Primary Purpose: Treatment
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