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Anti-CD19 and Anti-CD22 Immunotoxins in Treating Patients With Refractory or Relapsed B-Cell Acute Lymphoblastic Leukemia

Leukemia Clinical Trial

Official title:
A Phase I Study of Combination Therapy With Anti-CD19 and Anti-CD22 Immunotoxins (Combotox) in Adults With Refractory/Relapse Acute Lymphoblastic Leukemia

Clinical Trial Summary

RATIONALE: Immunotoxins, such as anti-CD19 and anti-CD22, can find cancer cells that express CD19 and CD22 and kill them without harming normal cells. This may be an effective treatment for B-cell acute lymphoblastic leukemia. PURPOSE: This phase I trial is studying the side effects and best dose of anti-CD19 and anti-CD22 immunotoxins in treating patients with refractory or relapsed B-cell acute lymphoblastic leukemia.

Clinical Trial Description

OBJECTIVES: - Determine the maximum tolerated dose of deglycosylated ricin A chain-conjugated anti-CD19 and anti-CD22 immunotoxins (Combotox) in patients with refractory or relapsed B-cell acute lymphoblastic leukemia. - Determine the toxicity of Combotox in these patients. - Determine the pharmacokinetic (PK) profile of Combotox in these patients. - Determine any antitumor activity of Combotox, in terms of the percentage of blasts in bone marrow and peripheral blood. - Determine the levels of human antimouse and human anti-dgA antibodies in patients treated with Combotox. - Determine if there is a correlation between PK parameters and toxicity of Combotox in these patients. - Determine if the expression of the CD19 and CD22 cell surface antigens is affected by Combotox. OUTLINE: This is a dose-escalation study. Patients receive deglycosylated ricin A chain-conjugated anti-CD19 and anti-CD22 immunotoxins (Combotox) IV over 4 hours on days 1, 3, and 5 in the absence of disease progression or unacceptable toxicity. Cohorts of patients receive escalating doses of Combotox until the maximum tolerated dose is determined. After completion of study treatment, patients are followed periodically. PROJECTED ACCRUAL: A total of 20 patients will be accrued for this study. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00450944
Study type Interventional
Source Albert Einstein College of Medicine
Contact
Status Completed
Phase Phase 1
Start date February 22, 2006
Completion date April 1, 2010
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