Leukemia Clinical Trial
Official title:
Phase I/II Study of 5-aza-2'-Deoxycytidine and Valproic Acid in Patients With Relapsed/Refractory Leukemia or Myelodysplastic Syndromes
Valproic acid is a medication that is currently used in the prevention of seizures, bipolar disorder, and migraine headaches. Researchers hope that it may improve the effects of decitabine. Decitabine is a chemotherapy drug with known activity in leukemia and myelodysplastic syndromes.
Recent studies have shown synergy between demethylating agents and histone deacetylase
inhibitors. It has been shown that both DNA methylation and histone deacetylation work
together in affecting gene expression.
Therefore, drugs that inhibit DNA methylation and those that inhibit histone deacetylase can
reactivate silenced genes in combination better than they can individually. Decitabine (5
aza-2'deoxycytidine), a drug that produces marked DNA hypomethylator, has demonstrated
antileukemic activity at low doses. There are several drugs that have been shown to have
histone acetylase activity. One of these is valproic acid that has been used safely for many
years as an anti-seizure medication.
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