Leukemia Clinical Trial
Official title:
Phase II Study of Doxercalciferol for the Treatment of Myelodysplastic Syndromes
RATIONALE: Doxercalciferol may improve low blood cell counts and decrease the need for blood
transfusions and may be an effective treatment for myelodysplastic syndrome or chronic
myelomonocytic leukemia.
PURPOSE: Phase II trial to study the effectiveness of doxercalciferol in treating patients
who have myelodysplastic syndrome or chronic myelomonocytic leukemia.
OBJECTIVES:
- Determine the response rate of patients with myelodysplastic syndromes or chronic
myelomonocytic leukemia treated with doxercalciferol.
- Determine the toxicity profile of this drug in these patients.
- Determine the time to progression and overall survival of patients treated with this
drug.
OUTLINE: Patients receive oral doxercalciferol daily for 12 weeks. Treatment continues in the
absence of disease progression or unacceptable toxicity.
PROJECTED ACCRUAL: Approximately 41 patients will be accrued for this study.
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