Leukemia Clinical Trial
Official title:
Phase II Study of Continuous Infusion Carboplatin and Topotecan in the Treamtment of Relapsed Acute Myelogenous Leukemia (AML)
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing
so they stop growing or die. Combining more than one drug may kill more tumor cells.
PURPOSE: Phase II trial to study the effectiveness of combining carboplatin and topotecan in
treating patients with relapsed acute myelogenous leukemia.
OBJECTIVES: I. Determine the efficacy of a 5-day continuous infusion of carboplatin and
topotecan in patients with relapsed and refractory acute myelogenous leukemia (AML). II.
Assess the toxic effects of this treatment in these patients.
OUTLINE: Patients receive continuous intravenous infusions of topotecan and carboplatin for
5 days. Treatment repeats every 3-4 weeks during induction (two courses) and every 6-10
weeks during consolidation. No more than four courses of treatment are given. Patients are
followed every 6 months for 5 years.
;
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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