Leukemia Clinical Trial
Official title:
Bone Marrow Transplantation for Chronic Lymphocytic Leukemia
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing
so they stop growing or die. Combining chemotherapy with bone marrow transplantation may
allow the doctor to give higher doses of chemotherapy drugs and kill more cancer cells.
PURPOSE: Phase II trial to study the effectiveness of bone marrow transplantation in treating
patients with chronic lymphocytic leukemia.
OBJECTIVES: Examine the potential role for high dose cyclophosphamide, total body irradiation
and bone marrow transplantation for patients with chronic lymphocytic leukemia who are at
high risk for disease progression.
OUTLINE: Patients receive daily intravenous infusions of cyclophosphamide for two days,
followed by total body irradiation in four daily exposures. After completion of the total
body irradiation, allogeneic or autologous bone marrow is infused intravenously.
PROJECTED ACCRUAL: 50 patients are expected to be accrued.
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