Leukemia Clinical Trial
Official title:
PHASE II STUDY OF SIMULTANEOUS HOMOHARRINGTONINE (NSC 141633) AND ALPHA INTERFERON (IFN-A) THERAPY IN CHRONIC MYELOGENOUS LEUKEMIA (CML)
Phase II trial to study the effectiveness of homoharringtonine and interferon alfa in treating patients with chronic myelogenous leukemia. Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Interferon alfa may interfere with the growth of cancer cells. Combining chemotherapy with interferon alfa may kill more cancer cells.
OBJECTIVES:
I. Determine the efficacy of homoharringtonine administered simultaneously with interferon
alpha in achieving complete cytogenetic response in patients with chronic myelogenous
leukemia in chronic phase.
OUTLINE:
Single-Agent Chemotherapy plus Biological Response Modifier Therapy. Homoharringtonine, HH,
NSC-141633; plus Interferon alfa (Schering), IFN-A, NSC-377523.
;
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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