Leukemia, Myeloid Clinical Trial
Official title:
Treatment of Relapsed/Refractory Acute Myeloblastic Leukemia(AML) by Infusion of Donor High Dose Allogeneic Mismatched Hematopoietic Stem Cells After Chemotherapy
The purpose of this study is to evaluate the safety and efficiency of high dose allogeneic mismatched hematopoietic stem cells infusions after normal chemotherapy in patients with relapsed/refractory acute myeloid leukemia(AML).
The relapsed/refractory AML patients will receive
IA/DA/MA(I,Idamycin,D,Daunorubicin,M,Mitoxantrone,A,cytosine arabinoside) chemotherapy
followed by infusion of high dose allogeneic mismatched hematopoietic stem cells.
no graft-versus-host disease (GVHD) prevention will be conducted before transplantation.
Cytokine storm,GVHD snd donor graft will be detected post-transplantation.
;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT02916979 -
Myeloid-Derived Suppressor Cells and Checkpoint Immune Regulators' Expression in Allogeneic SCT Using FluBuATG
|
Phase 1 | |
Recruiting |
NCT04265963 -
CD123-Targeted CAR-T Cell Therapy for Relapsed/Refractory Acute Myeloid Leukemia
|
Phase 1/Phase 2 | |
Completed |
NCT00233909 -
A Trial of Gemtuzumab Ozogamicin (GO) in Combination With Zosuquidar in Patients With CD33 Positive Acute Myeloid Leukemia
|
Phase 1/Phase 2 | |
Terminated |
NCT04748848 -
A Safety, Tolerability and Preliminary Efficacy Study of CC-90011 in Combination With Venetoclax and Azacitidine in R/R Acute Myeloid Leukemia and Treatment-naïve Participants Not Eligible for Intensive Therapy
|
Phase 1 | |
Completed |
NCT04039100 -
Family Caregiver Ambassador Support for Family Caregivers of Patients With Hematological Disease
|
N/A | |
Recruiting |
NCT03600558 -
Efficacy of FLAG Regimen for the Treatment of Patients With AML
|
||
Completed |
NCT02538965 -
A Study of Lenalidomide in Pediatric Subjects With Relapsed or Refractory Acute Myeloid Leukemia
|
Phase 2 | |
Active, not recruiting |
NCT02333838 -
Reduced Toxicity Conditioning Prior to Unrelated Cord Cell Transplantation for High Risk Myeloid Malignancies
|
Phase 2 | |
Completed |
NCT01061177 -
Nilotinib in Newly Diagnosed Adult Philadelphia Chromosome and /or BCR-ABL Positive Chronic Myeloid Leukaemia in Chronic Phase
|
Phase 4 | |
Completed |
NCT00025662 -
Selective T-Cell Depletion to Reduce GVHD (Patients) Receiving Stem Cell Tx to Treat Leukemia, Lymphoma or MDS
|
Phase 2 | |
Terminated |
NCT02370888 -
Lenalidomide After Allo-Hematopoietic Cell Transplant (HCT) in Acute Myelogenous Leukemia (AML) and Myelodysplastic Syndromes (MDS) Subjects With Minimal Residual Disease
|
Phase 1 | |
Recruiting |
NCT05805605 -
Allo HSCT Using RIC and PTCy for Hematological Diseases
|
Phase 2 | |
Completed |
NCT01392989 -
Post T-plant Infusion of Allogeneic Cytokine Induced Killer (CIK) Cells as Consolidative Therapy in Myelodysplastic Syndromes/Myeloproliferative Disorders
|
Phase 2 | |
Terminated |
NCT00306332 -
T-cell and B-cell Depletion in Allogeneic Peripheral Blood Stem Cell Transplantation
|
Phase 3 | |
Completed |
NCT00451997 -
Gleevec/Low-Dose Ara-C Study for Elderly Patients With AML and Myelodysplastic Syndromes
|
Phase 2 | |
Recruiting |
NCT04310592 -
Natural Killer Cell (CYNK-001) Infusions in Adults With AML
|
Phase 1 | |
Recruiting |
NCT05458258 -
Studying Malnutrition And Sarcopenia In Older Adults With Acute Myeloid Leukemia
|
||
Completed |
NCT00065143 -
Clofarabine Plus Cytarabine in Patients With Previously Untreated Acute Myeloid Leukemia and High-risk Myelodysplastic Syndrome
|
Phase 2 | |
Recruiting |
NCT04789655 -
Study of CC-96191 in Participants With Relapsed or Refractory Acute Myeloid Leukemia
|
Phase 1 | |
Withdrawn |
NCT04406207 -
Endogenous Retroviruses in Acute Myeloid Leukemia
|