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Clinical Trial Summary

The investigators focused on patients with refractory acute leukemia or MDS and designed a phase 1 trial of escalated cladribine doses in the Cla-Flu-Bu RTC regimen using PK-guided myeloablative busulfan doses. This scheme allows combining different optimization of RTC experienced over years (Flu-Bu RTC, PK-guided myeloablative busulfan doses, a second purine analog cladribine) to approach a specific platform to treat refractory diseases.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT03235973
Study type Interventional
Source Institut Paoli-Calmettes
Contact Dominique Genre, MD
Phone +33491223778
Email drci.up@ipc.unicancer.fr
Status Recruiting
Phase Phase 1
Start date April 28, 2018
Completion date April 2021

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