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Clinical Trial Summary

Sarcopenia is defined as reduction in muscle mass and function according to the criteria of the European Working Group on Sarcopenia in older people. Initially described for elderly patients, it is also presented as a negative prognostic factor in overall survival in oncology in certain locations (lung, ENT pathways, colon, pancreas) and more controversially for hemopathies. Its screening by measurement of skeletal muscle mass by CT scan and / or PET scan against L3 and by physical functional tests is not routinely integrated despite international recommendations. Sarcopenia is one of the characteristics of patient fragility that can induce more complications, lengthen the average length of hospital stay and reduce overall survival. The PRONOPALL score, a predictor score for survival validated by a previous study, will be correlated with the presence (or absence) of sarcopenia at inclusion for patients with a solid tumor (breast, ovary, prostate cancer , kidney, lungs, pancreas, colorectal). A prospective study on 38 patients with metastatic cancer was carried out at the Victor Hugo clinic in Le Mans between 01/JUN/21 and 31/AUG/21 (SPACE, ClinicalTrials.gov number, NCT04714203): 25 patients were analyzable on the CT and PRONOPALL score data with a prevalence of sarcopenia of 60% and median overall survival of 14 months (unpublished data), clinical performance and muscle strength tests were not carried out (as in the publications cited above). A prospective study for the detection of sarcopenia is indicated by extending to blood diseases with the integration of clinical tests included in the initial APA (Adapted physical activity) assessment recommended for diagnosis.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms

  • Breast Neoplasms
  • Cancer Colon
  • Cancer Ovaries
  • Cancer Pancreas
  • Cancer Prostate
  • Cancer, Breast
  • Cancer, Kidney
  • Cancer, Lung
  • Cancer, Rectum
  • Hematologic Neoplasms
  • Kidney Neoplasms
  • Leukemia
  • Leukemia, Lymphocytic, Acute
  • Leukemia, Lymphocytic, Chronic
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Leukemia, Lymphoid
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive
  • Leukemia, Myeloid
  • Leukemia, Myeloid, Acute
  • Leukemia,Myeloid, Chronic
  • Lung Neoplasms
  • Metastatic Cancer
  • Myelodysplasia
  • Myeloma
  • Neoplasm Metastasis
  • Neoplasms
  • Neoplasms, Second Primary
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Rectal Neoplasms
  • Sarcopenia

NCT number NCT05154474
Study type Observational
Source Weprom
Contact Magali BALAVOINE
Phone +33(0)241682940
Email m.balavoine@ilcgroupe.fr
Status Not yet recruiting
Phase
Start date June 2022
Completion date August 2024

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