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Clinical Trial Summary

While neurocognitive impairments in attention, memory and executive functioning are commonly reported sequelae of childhood leukemia and brain tumors, studies have only recently begun to examine the treatment of attention deficits in this population. Numerous studies have examined the effectiveness of methylphenidate in the treatment of children with attention deficit hyperactivity disorder (ADHD). However, the effectiveness of this medication for improving attention and behavioral functioning in children with medical illnesses or brain injury are less clear.

Patients will be randomized to receive one week of Metadate CD (a controlled release form of methylphenidate, similar to Ritalin) and one week of placebo in a double-blind fashion.


Clinical Trial Description

n/a


Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment


Related Conditions & MeSH terms

  • Acute Disease
  • ALL, Childhood
  • Attention Deficit Disorder with Hyperactivity
  • Brain Neoplasms
  • Brain Neoplasms, Malignant
  • Brain Tumors
  • Cancer of Brain
  • Cancer of the Brain
  • Leukemia
  • Leukemia, Lymphoblastic
  • Leukemia, Lymphoblastic, Acute
  • Leukemia, Lymphoblastic, Acute, L1
  • Leukemia, Lymphoblastic, Acute, L2
  • Leukemia, Lymphoblastic, Acute, Philadelphia-Positive
  • Leukemia, Lymphocytic, Acute
  • Leukemia, Lymphocytic, Acute, L1
  • Leukemia, Lymphocytic, Acute, L2
  • Leukemia, Lymphoid
  • Lymphoblastic Leukemia
  • Lymphoblastic Leukemia, Acute
  • Lymphoblastic Leukemia, Acute, Childhood
  • Lymphoblastic Leukemia, Acute, L1
  • Lymphoblastic Leukemia, Acute, L2
  • Lymphoblastic Lymphoma
  • Lymphocytic Leukemia, Acute
  • Lymphocytic Leukemia, L1
  • Lymphocytic Leukemia, L2
  • Malignant Primary Brain Tumors
  • Neoplasms
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT number NCT01100658
Study type Interventional
Source University of Minnesota - Clinical and Translational Science Institute
Contact
Status Terminated
Phase N/A
Start date May 2010
Completion date November 2010

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