Latent Tuberculosis Clinical Trial
— ACEOfficial title:
Improving the Detection of Active Tuberculosis in Accident and Emergency (A&E) Departments
Tuberculosis (TB) control remains a public health challenge. Many people in the UK do not have a general practitioner (GP) registration and their only interaction with the NHS is via Accident and Emergency (A&E) Departments of hospitals. This is often the case for those in hard to reach groups, who are also those often at highest risk of TB. This study seeks to assess whether A&E Departments are effective sites for the identification and onward management of TB, both in its latent and active forms.
Status | Not yet recruiting |
Enrollment | 1000 |
Est. completion date | December 2017 |
Est. primary completion date | May 2017 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 16 Years and older |
Eligibility |
Inclusion Criteria: 1. Individuals 16 years or older, who are new entrants from high incidence countries who have arrived in the UK within the past 2 years or those born in high incidence countries who entered the UK more than five years ago, but have spent more than one year (cumulative) in the past five years in a high incidence country. 2. Those with social risk factors who have signs and/or symptoms of TB. Exclusion Criteria: 1. Individuals who are under 16 years 2. Individuals who were born in the UK or a low incidence countries and do not have risk factors |
Observational Model: Cohort, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
United Kingdom | Barts NHS Trust | London | |
United Kingdom | Ealing Hospital | London | |
United Kingdom | West Middlesex Hospital NHS Trust | London |
Lead Sponsor | Collaborator |
---|---|
Public Health England |
United Kingdom,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | xray diagnosis of active TB | clinical signs and symptoms on xray | 1 year | No |
Secondary | diagnosis of latent TB | positive blood test result by interferon gamma release assay (IGRA) in line with the manufacturer instructons for the test | 1 year | No |
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