| Eligibility |
Inclusion Criteria:
1. Signed informed consent obtained before any trial-related activities
2. Healthy men or women aged 18 to = 55 years on the day of consenting
3. Ability to comprehend the full nature and purpose of the study, including possible
risks and side effects; ability to cooperate with the investigator and to comply with
the requirements of the entire study
4. All female participants of childbearing potential, defined as all woman
physiologically capable of becoming pregnant, must have a negative pregnancy test at
screening
5. Willingness not to become pregnant or to father a child during the study up to 182
days after the first vaccination by practicing reliable methods of contraception
6. Availability during the duration of the trial
Exclusion Criteria:
1. Participation in another investigational clinical study (including exposure to an IMP
or device) within four weeks before the screening visit or planned concurrent
participation in another clinical study before study completion
2. History of immunodeficiency, known HIV infection or current hepatitis B/C infection
3. History of drug addiction including alcohol dependence within the last two years
4. Inability or unwillingness to avoid intake of more than around 20g alcohol per day
during 48 hours after each vaccination
5. Vaccination within four weeks prior to first vaccination or planning to receive any
non-study vaccine within 182 days after the first vaccination
6. Prior receipt of any Lassa vaccine
7. Recent infection within one week prior to Screening visit
8. Blood donations including plasma donations, 90 days prior to Screening visit and
anticipated blood, plasma, tissue, sperm or organ donation, throughout the study until
end of treatment period
9. Clinically relevant history of renal, hepatic, gastrointestinal, cardiovascular,
respiratory, skin, hematological, endocrine, inflammatory, autoimmune or neurological
diseases or clinically relevant abnormal laboratory values, that in the opinion of the
investigator may interfere with the aim of the study
10. History of neoplastic disease (excluding non-melanoma skin cancer that was
successfully treated) within the past five years or a history of any hematological
malignancy
11. Behavioral, cognitive, or psychiatric condition that in the opinion of the
investigator affects the ability of the participant to understand and cooperate with
the study protocol
12. History of severe adverse reactions to vaccine administration, including anaphylaxis
and related symptoms, such as urticaria, respiratory difficulty, angioedema and
abdominal pain to vaccines, or history of allergic reaction likely to be exacerbated
by any component of the vaccine
13. History of or present hearing deficit
14. Present thrombocytopenia and/or history of thrombocytopenia and/or bleeding disorders.
15. History of anaphylaxis to drugs or other allergic reactions, which the investigator
considers compromising the safety of the volunteer
16. Use of medication during two weeks before the first vaccination and throughout the
study, which the investigator considers affecting the validity of the study, except
hormonal contraception or hormonal replacement therapy in female participants (prior
to taking any medication within 72 hours before study vaccination, the participant
should consult the investigator)
17. Use of immunosuppressive drugs like corticosteroids (excluding topical preparations)
within 30 days prior to the first vaccination or anticipated use before completion of
day 182
18. Receipt of blood products or immunoglobulins within 120 days prior to the Screening
Visit or anticipated receipt of any blood product or immunoglobulin before completion
of day 182
19. Pregnancy or lactation at screening or planning to become pregnant before completion
of day 182
20. Unreliable contraception Methods
21. Persons in a direct relationship with the sponsor, an investigator or other study team
members. Direct dependent relationships include close relatives (i.e. children,
parents, partner/spouse, siblings) as well as employees of the clinical study site or
the sponsor
22. Individuals who are living and/or working with severely immunocompromised people,
children under 15 months old or pregnant women
23. Participants who travelled within one year prior to the first vaccination or plan to
travel during the study to an endemic country
24. A rash, dermatological condition or tattoos that would, in the opinion of the
Investigator, interfere with injection site reaction rating
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