Blood Flow Index as an Indicator of Successful Peripheral Nerve Block

Laser Clinical Trial

Official title:

Blood Flow Index as an Indicator of Successful Peripheral Nerve Block : A Prospective Observational Study Using Laser Speckle Contrast Imaging.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03169517
• Other study ID #: TJMZK20170325
• Status: Completed
• Phase: N/A
• First received: May 24, 2017
• Last updated: September 4, 2017
• Start date: May 27, 2017
• Est. completion date: September 4, 2017

Study information

• Verified date: September 2017
• Source: Huazhong University of Science and Technology
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Laser speckle contrast imaging (LSCI) allows real-time, non-invasive, quantitative measurements of regional blood flow. The aim of this prospective observational study was to evaluate the blood flow changes by LSCI after peripheral nerve block and determine whether this novel optical technique can be used as a reliable indicator of successful blocks.

Description:

Methods: One hundred adult patients scheduled for elective upper or lower limb surgery with peripheral nerve block will receive LSCI measurements and pinprick sensory tests before the block and at 5-min intervals till 30 min after the block. The sensitivity, specificity of LSCI as a diagnostic method will be determined by receiver operator characteristic analysis.

Clinical Implications: LSCI with quantitative data could be used as an indicator of successful blocks.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 110
• Est. completion date: September 4, 2017
• Est. primary completion date: September 4, 2017
• Gender: All
• Age group: 18 Years to 75 Years

Eligibility

Inclusion Criteria:

• informed consent

• American Society of Anesthesiologists physical status?-?

• Undergo elective upper or lower limb surgery with peripheral nerve block

Exclusion Criteria:

• refusal to participate in the study

• peripheral vascular disease

• digit injury or deficiency

• colored or infected fingernails/toenails

• BMI>35

• those who had taken vasodilatory drugs before surgery

• preoperative analgesic medications

• Any contraindications to peripheral nerve block such as coagulation abnormalities, allergy to local anaesthetics, peripheral neuropathy.

Related Conditions & MeSH terms

• Laser

Locations

Country	Name	City	State
China	Tongji Hospital	Wuhan	Hubei

Sponsors (1)

Lead Sponsor	Collaborator
Huazhong University of Science and Technology

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	diagnostic power of LSCI and pinprick sensory tests for predicting successful and failed blocks	sensitivity and specificity	at 5-min intervals till 30 min after regional block
Secondary	blood flow index	perfusion unit(PU)	5 min before regional block and at 5-min intervals till 30 min after regional block