Larynx Clinical Trial - Laryngeal Allograft Transplantation

Status Enrolling by invitation

Clinical Trial Summary

The purpose of this proposed study is to obtain safety and efficacy data on human laryngeal allograft transplantation in an effort to safely use these procedures as a viable reconstructive option for patients with severe laryngeal or laryngotracheal incompetence.

Clinical Trial Description

Patients with severe laryngeal or laryngotracheal incompetence without other reconstructive options will be considered for cadaveric laryngotracheal transplantation. Data will be collected from 10 patients and will include length of hospital stay, short-term complications, long-term complications, hospital readmission, return trips to the operating room (OR), rejection episodes and severity, swallowing function, ability to have tracheotomy tube decannulated, voice parameters, pulmonary function, development of anti-donor antibodies, and quality of life scores. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03269396
Study type	Interventional
Source	Mayo Clinic
Contact
Status	Enrolling by invitation
Phase	N/A
Start date	May 1, 2022
Completion date	May 2028

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