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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT02840396
Other study ID # SNF325130_156937_2
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date March 2016
Est. completion date July 2017

Study information

Verified date October 2019
Source University of Fribourg
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The purpose of this study is to investigate the effects of repetitive transcranial magnetic stimulation (rTMS) over the dorsolateral prefrontal cortex (DLPFC) on language production.


Description:

Background:

Several studies investigating healthy or clinical populations have shown that (r)TMS applied over the dorsolateral prefrontal cortex (DLPFC) has an effect on language-related processes such as verbal working memory (Osaka et al., 2007), sentence comprehension (Cotelli et al., 2011) and language switching (Holtzheimer et al., 2005, Nardone et al., 2011).

Clinical observations and neuroimaging studies seem to confirm the role of executive functions and frontal structures in language processing in monolingual and bilingual subjects (e.g. Fabbro et al., 2000, Abutalebi & Green 2007). However, only few studies investigated the effects of modulation of cognitive control-networks on lexical access.

Aim and procedure:

The study will investigate the role of the DLPFC and executive functioning in L1 and L2 language processing. The core question is whether rTMS over the DLPFC will influence lexical access and language production.

Each participant will take part in two sessions: 1. rTMS session 2. Sham rTMS session. After the application of rTMS/Sham rTMS, the participants will conduct two language tasks (translation, picture naming) and a non-verbal task, while the EEG is recorded.


Recruitment information / eligibility

Status Completed
Enrollment 22
Est. completion date July 2017
Est. primary completion date June 2017
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years to 45 Years
Eligibility Inclusion Criteria:

- L1 French, knowledge of English as a foreign language

- 18-45 years of age

- Right-handedness

Exclusion Criteria:

- epilepsy /family history of epilepsy

- brain surgery, traumatic brain injuries

- cardiac pacemaker, metallic objects in the body

- history of neurological diseases or psychiatric disorders

- drug use (alcohol, psychoactive medication)

- developmental language disorder

Study Design


Related Conditions & MeSH terms


Intervention

Device:
rTMS
repetitive TMS (rTMS) can lead to temporary increases or decreases (depending on the protocol used) in excitability of the targeted area. This change in excitability has been shown to last beyond the duration of the stimulation.
Sham rTMS
Sham rTMS (or placebo rTMS) refers to a control condition in which no physiological effect on the targeted cortical region occurs.

Locations

Country Name City State
Switzerland Laboratory for Cognitive and Neurological Sciences Fribourg

Sponsors (2)

Lead Sponsor Collaborator
Jean-Marie Annoni University Hospital Inselspital, Berne

Country where clinical trial is conducted

Switzerland, 

References & Publications (6)

Abutalebi J, Green D. Bilingual language production: The neurocognition of language representation and control. Journal of Neurolinguistics, 20, 242-275, 2007.

Cotelli M, Calabria M, Manenti R, Rosini S, Zanetti O, Cappa SF, Miniussi C. Improved language performance in Alzheimer disease following brain stimulation. J Neurol Neurosurg Psychiatry. 2011 Jul;82(7):794-7. doi: 10.1136/jnnp.2009.197848. Epub 2010 Jun 23. — View Citation

Fabbro F, Skrap M, Aglioti S. Pathological switching between languages after frontal lesions in a bilingual patient. J Neurol Neurosurg Psychiatry. 2000 May;68(5):650-2. — View Citation

Holtzheimer P, Fawaz W, Wilson C, Avery D. Repetitive transcranial magnetic stimulation may induce language switching in bilingual patients. Brain Lang. 2005 Sep;94(3):274-7. — View Citation

Nardone R, De Blasi P, Bergmann J, Caleri F, Tezzon F, Ladurner G, Golaszewski S, Trinka E. Theta burst stimulation of dorsolateral prefrontal cortex modulates pathological language switching: A case report. Neurosci Lett. 2011 Jan 10;487(3):378-82. doi: 10.1016/j.neulet.2010.10.060. Epub 2010 Oct 29. — View Citation

Osaka N, Otsuka Y, Hirose N, Ikeda T, Mima T, Fukuyama H, Osaka M. Transcranial magnetic stimulation (TMS) applied to left dorsolateral prefrontal cortex disrupts verbal working memory performance in humans. Neurosci Lett. 2007 May 18;418(3):232-5. Epub 2007 Apr 8. — View Citation

Outcome

Type Measure Description Time frame Safety issue
Primary Language production Picture naming task and word translation task within 30 mins after rTMS/sham rTMS
Secondary non-verbal executive functions task within 30 mins after rTMS/sham rTMS
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