Clinical Trials Logo
  1. Home
  2. Lactic Acidosis
  3. NCT00004353
  4. Details
NCT00004353 Clinical Trial

Study of the Metabolism of Pyruvate and Related Problems in Patients With Lactic Acidemia

Lactic Acidosis Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00004353
Other study ID # NCRR-M01RR00827-0071
Secondary ID UCSD-071
Status Completed
Phase N/A
First received October 18, 1999
Last updated July 9, 2008
Start date December 1978

Study information
Verified date April 2002
Source National Center for Research Resources (NCRR)
Contact n/a
Is FDA regulated No
Health authority United States: Federal Government
Study type Observational

Clinical Trial Summary

OBJECTIVES: I. Study the metabolism of pyruvate and related problems in patients with lactic acidemia.

II. Define the nature of the metabolic defect.

Description:

PROTOCOL OUTLINE: Patients fast for 6 hours. Glucagon IM is administered after the 6 hour fast. Glucose level is measured at 0, 15, 30, 45, 60, and 90 minutes.

In children of sufficient size, alanine and lactic acid should also be measured at each or most of these time points.

Fasting continues for at least 18 hours. Glucagon IM is administered again at end of fast. Glucose level is measured at time 0, 15, 30, 45, 60, and 90 minutes.

Recruitment information / eligibility
Status Completed
Enrollment 35
Est. completion date
Est. primary completion date
Accepts healthy volunteers No
Gender Both
Age group N/A and older
Eligibility PROTOCOL ENTRY CRITERIA:

- Diagnostically documented elevation in lactate, pyruvate, and/or alanine levels in lactic acidemia patients

Study Design

N/A

Related Conditions & MeSH terms

Locations
Country Name City State
United States University of California San Diego Medical Center San Diego California

Sponsors (2)
Lead Sponsor Collaborator
National Center for Research Resources (NCRR) University of California, San Diego

Country where clinical trial is conducted

United States, 

See also
  Status Clinical Trial Phase
Withdrawn NCT00638040 - The Gene Expression Studies of the Role of Tumor Microenvironments in Tumor Progression N/A
Completed NCT00004493 - Phase II Pilot Randomized Study of Sodium Dichloroacetate in Patients With Congenital Lactic Acidemia Phase 2
Completed NCT00004490 - Phase III Randomized Study of Sodium Dichloroacetate in Children With Congenital Lactic Acidosis Phase 3
Withdrawn NCT03122678 - Thiamine Supplementation in Patients With Septic Shock Phase 1
Recruiting NCT03126890 - Investigation of the Correlation Between Plasma Concentration of Linezolid Antibiotic and Treatment Response and Adverse Reactions
Completed NCT01873859 - Safety of Continuing Metformin in Diabetic Patients With Normal Kidney Function Receiving Contrast Media N/A
Terminated NCT01354652 - Lactic Acidosis During Entecavir(ETV)Treatment Phase 4
Terminated NCT02974257 - Thiamine vs. Placebo to Increase Oxygen Consumption After Cardiac Arrest Phase 2
Active, not recruiting NCT05984186 - Wingate-type Exercise Test to Evaluate the Effect of High Velocity Therapy on Recovery Sensation and Blood Lactate Decline
Completed NCT01139463 - Study of Blood Lactate Levels in Patients Treated With Antipsychotics N/A
Completed NCT01901419 - Nitroglycerin Infusion During Cardiac Surgery N/A
Completed NCT00202228 - Lactate Metabolism Study in HIV Infected Persons Phase 4
Completed NCT04975906 - The Threshold of Serum Anion Gap as a Screening Tool for Organic Acidosis
Completed NCT00942123 - Study On the Role of Mitochondrial Dysfunction in the Pathogenesis of Metformin-associated Lactic Acidosis N/A
Withdrawn NCT03723993 - Remote Ischemic Preconditioning During Cardiopulmonary Bypass N/A
Withdrawn NCT01973504 - Phase 2c Dose Comparison Study of MP4OX in Trauma Phase 2
Completed NCT00015015 - Dichloroacetate Kinetics, Metabolism and Toxicology N/A
Completed NCT03466528 - Alcohol: Thiamine and or Magnesium 1 Phase 2/Phase 3