Lactate Clinical Trial
Official title:
Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences,
Using sodium lactate Ringer's injection resuscitate septic shock patients and Compared with other solution, in order to make clear whether can improve the prognosis.
Experimental evidence repeatedly demonstrated that the shock patients can use substrates
other than glucose to sustain increased activity, including lactate.Increased lactate can be
the consequence of anaerobic metabolism, i.e., the formation of lactate in the presence of
low oxygen. However, emerging evidence demonstrated that in patients with sepsis increased
lactate seems predominantly non-hypoxic/ischemic and rather the consequence of increased
glycolysis. Utilization of lactate as an alternative fuel may be an adaptive response to
maximize energy function and limit substrate reduction.Uptake of exogenous lactate has
indeed been demonstrated after traumatic brain injury and acute heart failure in humans.
The investigators assume that administration of supplemental lactate significantly
contributes to energy metabolism in septic shock, which can have beneficial help for septic
shock resuscitation.
Inclusion criteria:diagnosis in patients with septic shock and age 18 years old or more.
Exclusion criteria: pregnant women and nursing mothers, severe liver failure with child
class C , use linezolid anti-infection treatment, pheochromocytoma patients, CVVH therapy
patients, malignant tumor patients, using epinephrine.
The investigators will use sodium lactate Ringer's injection resuscitate septic shock
patients and Compared with other solution, the organ function monitoring include heart,
kidney,and brain. Others study endpoints include 28-day mortality,hospitalized mortality.
;
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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