Knee Osteoarthrosis Clinical Trial
Official title:
Treatment of Knee Arthrosis: Platelet-derived Growth Factors vs. Hyaluronic Acid. A Phase II-III Randomized Controlled Trial
Primary aim of this trial was to assess efficacy three intraarticular injections of platelet lysate when compared to hyaluronic acid. Additional objectives were to compare the treatment groups in terms of a number of functional scales and of number of adverse events.
Intra-articular injections of hyaluronic acid are effective in improving symptoms and slow
disease progression, but are not able to revert the damage mechanism and trigger cartilage
healing.
Growth factors included in PRP could stimulate cartilage repair, normalize synovial fluid
viscoelasticity, induce a correction in tissue damage, improve articular function, control
pain and ameliorate quality of life.
Primary aim of this trial was to assess, among patients with grade II/III osteoarthrosis of
the knee, efficacy (as determined by improvement at MRI 6 months after the first injection)
of three intraarticular injections of platelet lysate when compared to hyaluronic acid.
Additional objectives were to compare the treatment groups in terms of a number of functional
scales (WOMAC, Lysholm, Tegner Knee, Scale, AKS, Lequesne, VAS) and of number of adverse
events.
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| Status | Clinical Trial | Phase | |
|---|---|---|---|
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