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Sex Steroids Balance for Metabolic and Reproductive Health in Klinefelter Syndrome — KLIN-HEALTH  

Klinefelter Syndrome Clinical Trial

Official title:
Dissecting the Importance of Sex Steroids Balance for Metabolic and Reproductive Health in Men With Klinefelter Syndrome: a Randomized Controlled Study

Clinical Trial Summary

The study seeks primarily to determine whether modulation of systemic and testicular sex steroids balance by aromatase inhibitors will positively affect the metabolic health and spermatogenesis of men with Klinefelter syndrome (KFS) as compared to the current state of the art for each issue. Secondary objectives of this study are (i) to unravel the heterogeneity of the reproductive and metabolic phenotype of men with KFS by performing a multi-omic analysis in a large cohort at baseline; (ii) to evaluate the efficacy of semaglutide-induced weight loss to achieve metabolic and reproductive benefit in men with Klinefelter syndrome as compared to standard testosterone replacement; (ii) to assess whether addition of hCG to aromatase inhibitors further increases intratesticular testosterone and promotes spermatogenesis in men with KFS.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05586802
Study type Interventional
Source University of Lausanne Hospitals
Contact GEORGIOS PAPADAKIS, MD
Phone +41795560308
Email georgios.papadakis@chuv.ch
Status Recruiting
Phase Phase 3
Start date March 21, 2023
Completion date April 1, 2026
View Details
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