Klinefelter Syndrome Clinical Trial
Official title:
Fertility Preservation in Cases of Spermatogenesis Failure : Prospective Study for Klinefelter Syndrome With Non-mosaic Karyotype (47, XXY, Homogeneous)
Klinefelter Syndrome (KS) is the most common sex chromosomal abnormalities (1/600 newborn
males), and is characterized by a hypergonadism hypogonadism. Until few years ago, mostly
non-mosaic KS was considered as a model of a complete male infertility although few KS (4-8%)
have an oligospermia. Recent studies in adult with non-mosaic KS reported the possibility of
sperm retrieval by testicular biopsy (TESE) in around 50% cases and more than some
pregnancies have been obtained after TESE with Intracytoplasmic Sperm Injection (ICSI). Since
1997, more than one hundred births are described.
As some studies shown a decrease of successful sperm retrieval with the increasing of age, we
plan to compare the potential of sperm retrieval between two groups "adult" (23-55 years) and
"young" after the onset of puberty (15-22 years). The study will be performed by searching
spermatozoa on two seminal analyses spaced out 3 months followed by a testicular biopsy if
the azoospermia is confirmed on semen analyses.
n/a
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT03396562 -
The eXtroardinarY Babies Study: Natural History of Health and Neurodevelopment in Infants and Young Children With Sex Chromosome Trisomy
|
||
Completed |
NCT02526628 -
Thrombosis and Neurocognition in Klinefelter Syndrome
|
||
Completed |
NCT01690013 -
Life Quality and Health in Patients With Klinefelter Syndrome
|
N/A | |
Completed |
NCT01678261 -
X-chromosome Inactivation, Epigenetics and the Transcriptome
|
N/A | |
Completed |
NCT02787486 -
Expanded Noninvasive Genomic Medical Assessment: The Enigma Study
|
||
Completed |
NCT03325647 -
TESTO: Testosterone Effects on Short-Term Outcomes in Infants With XXY
|
Phase 4 | |
Enrolling by invitation |
NCT03836300 -
Parent and Infant Inter(X)Action Intervention (PIXI)
|
N/A | |
Recruiting |
NCT05498090 -
Interrogating Fatty Acid Metabolism Impairment and Clinical Correlates in Males With Klinefelter Syndrome
|
Phase 4 | |
Completed |
NCT00999310 -
Neuropsychologic, Neuroradiologic, Endocrinologic, and Genetic Aspects of Klinefelter Syndrome
|
N/A | |
Completed |
NCT02408445 -
Body Composition in Infants With Klinefelter Syndrome and Effects of Testosterone Treatment
|
Phase 4 | |
Completed |
NCT00896272 -
Adaptation Among Adolescents and Adults With Klinefelter Syndrome
|
||
Completed |
NCT02723305 -
Cardiometabolic Profiles of Boys With Klinefelter Syndrome
|
||
Completed |
NCT05581147 -
Thyroid Function and Structure IN Klinefelter Syndrome
|
||
Recruiting |
NCT05586802 -
Sex Steroids Balance for Metabolic and Reproductive Health in Klinefelter Syndrome
|
Phase 3 | |
Active, not recruiting |
NCT02430584 -
Whole Blood Specimen Collection From Pregnant Subjects
|
||
Completed |
NCT01817296 -
Klinefelter Fertility Preservation
|
N/A | |
Completed |
NCT01585831 -
Study of Psychological and Motor Effects of Testosterone in Adolescents With XXY/Klinefelter Syndrome
|
N/A | |
Completed |
NCT01206270 -
Androgen for Leydig Cell Proliferation
|
Phase 2/Phase 3 | |
Withdrawn |
NCT00347464 -
Adaptive Behavior Assessment of Men With 49, XXXXY, Klinefelter Syndrome
|
N/A | |
Recruiting |
NCT05425953 -
Endocrine, Metabolic, Cardiovascular and Immunological Aspects of Sex Chromosome Abnormalities in Relation to Genotype
|