Kinesiophobia Clinical Trial
— EchoKinésioOfficial title:
Impact of Kinesiophobia on Descending Corticospinal and Bulbospinal Projections During Experimental Pain : A Randomised Controlled Trial
Verified date | June 2024 |
Source | Université de Sherbrooke |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Fear of movement (kinesiophobia) is a phenomenon commonly observed in people suffering from chronic pain. The aims of this project are to better understand the neurophysiological basis of this phenomenon, in particular 1) the effect of kinesiophobia (induced by nocebo intervention) on the excitability of corticospinal projections and 2) the association between kinesiophobia and top-down inhibitory mechanisms.
Status | Completed |
Enrollment | 24 |
Est. completion date | January 29, 2024 |
Est. primary completion date | July 29, 2023 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Aged 18 years old or older - Healthy Volunteers - Capable of understanding instructions - Abstain from tobacco and caffeine 2 hours before data collection - Abstain from short-acting analgesics 6 hours before data collection Exclusion Criteria: - A painful condition or chronic pain - Neurological disorders - Shoulder pathology - Skin diseases - Capsaicin allergy - Raynaud's syndrome - Epilepsy - Intracranial metallic foreign bodies, hearing aids and cochlear implants |
Country | Name | City | State |
---|---|---|---|
Canada | Centre de Recherche sur le Vieillissement | Sherbrooke | Quebec |
Lead Sponsor | Collaborator |
---|---|
Université de Sherbrooke |
Canada,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Corticospinal excitability | The corticospinal excitability will be assessed using motor evoked potentials at different intensity of stimulation (from motor threshold to maximal amplitude response). | 1 hour | |
Secondary | downward inhibition of pain | Inhibitory mechanisms will be assessed by comparing pain levels (measured using a computerized visual analog scale [0 = no pain; 10 = worst pain imaginable]) evoked by a test stimulus before and after a conditioning stimulus.
Pain levels evoked by the test stimulus before the conditioning stimulus will be subtracted from pain levels evoked by the test stimulus after the pain stimulus, such that a positive score represents increased pain (hyperalgesia) and a negative score represents decreased pain (hypoalgesia, i.e., inhibitory mechanisms). |
1 hour |
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