Kidney Transplant Clinical Trial
Official title:
A Prospective Comparison of the Magnitude and Character of the Immune Response to Influenza Vaccine in Immunosuppressed Renal Transplant Patients and Healthy Age-matched Volunteers
Influenza (Flu) vaccine is recommended for kidney transplant patients who are at least 6
months post-transplant. The influenza vaccine stimulates the immune system to builds
protective antibodies against the flu virus.
Previous research has shown that adult kidney transplant patients are not able to form as
much of these protective antibodies as compared to healthy volunteers. Research has also
suggested that different immunosuppressive medicines may have different effects on antibody
formation. In this study, we hope to evaluate these differences in more detail.
In recent years, increasingly effective, but also increasingly complex, immunosuppressive
regimens have been developed, however, there has been little detailed systematic study of
the immune changes that occur in response to vaccination with these newer immunosuppressive
regimens.Current policies on vaccination of transplant recipients are generic and continue
to be based on old concepts rather than on any new understanding of the effects of these
newer therapies on the immune system.
We hope to improve our understanding of the effects of the immunosuppressive regimens in use
today (calcineurin-inhibitor, or CNI, and sirolimus-based regimens) on immune response to
flu vaccine. Such knowledge will be critical to helping clinicians develop strategies for
getting desirable immune responses while not causing rejection.
n/a
Observational Model: Cohort, Time Perspective: Prospective
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