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Clinical Trial Summary

Prospective, follow-up study of kidney transplant recipients treated with alemtuzumab anti-rejection therapy for severe or glucocorticoid-resistant kidney transplant rejection.


Clinical Trial Description

Study design: Prospective observational cohort study. Study population: Adult patients who are treated with alemtuzumab for severe or glucocorticoid-resistant kidney transplant rejection. Intervention (if applicable): Not applicable. Main study parameters/endpoints: Lymphocyte (subtype) repopulation, serious infections, one-year graft survival, alemtuzumab plasma levels, intra-cellular signalling of repopulated T and B cells, cytokine-levels, donor-specificity of repopulated T cells, differences pre- and post-treatment of donor-derived cell-free DNA, plasma nucleosomes, urinary chemokines, urinary extracellular vesicles, breath-pattern analysis. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06100965
Study type Observational
Source Erasmus Medical Center
Contact Lukas K van Vugt, Drs.
Phone 0031 10 704 0704
Email l.k.vanvugt@erasmusmc.nl
Status Recruiting
Phase
Start date December 1, 2023
Completion date July 1, 2026

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