KoreaN Cohort Study for Outcome in Patients With Kidney Transplantation (KNOW-KT)

Kidney Transplant Recipients Clinical Trial

— KNOW-KT  

Official title:

KoreaN Cohort Study for Outcome in Patients With Kidney Transplantation : A 9-year Longitudinal Cohort Study of the Kidney Transplantation (KNOW-KT)

Clinical Trial Details — Status: Enrolling by invitation

Administrative data

• NCT number: NCT02042963
• Other study ID #: KNOW-KT
• Status: Enrolling by invitation
• Phase: N/A
• First received: January 20, 2014
• Last updated: January 20, 2014
• Start date: March 2012

Study information

• Verified date: January 2014
• Source: Seoul National University Hospital
• Contact: n/a
• Is FDA regulated: No
• Health authority: South Korea: Korea Centers for Disease Control and Prevention
• Study type: Observational [Patient Registry]

Clinical Trial Summary

KNOW-KT (KoreaN cohort study for Outcome in patients With KT: A 9-year Longitudinal cohort study of the Korean adult KT patients), funded by Korea Center for Disease Control and Prevention (KCDC) was established in 2012 by a group of transplant physicians, transplant surgeons, nephrologists, epidemiologists, and biostatisticians in Korea.

We aimed to establish an adult KT cohort, to investigate the renal allograft outcomes, mortality, complications, and to explore traditional or nontraditional risk factors for morbidity and mortality. We established a bio-bank to integrate clinical and biological information. Here, we report design and method of the KNOW-KT.

Recruitment information / eligibility

• Status: Enrolling by invitation
• Enrollment: 1000
• Est. primary completion date: February 2021
• Accepts healthy volunteers: No
• Gender: Both
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• Recipients and Donors of kidney transplant

Exclusion Criteria:

• Multi-organ transplant recipients

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Complications After Kidney Transplant
• Kidney Transplant Recipients

Locations

Country	Name	City	State
Korea, Republic of	Seoul National Univeristy Hospital	Seoul

Sponsors (11)

Lead Sponsor	Collaborator
Seoul National University Hospital	Asan Medical Center, Chonbuk National University Medical School, Gachon University Gil Medical Center, Keimyung University Dongsan Medical Center, Korea University, Kyungpook National University, Medical Research Collaborating Center, Seoul, Korea, Samsung Medical Center, Seoul National University College of Medicine, Yonsei University

Country where clinical trial is conducted

Korea, Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	overall mortality		9 years	No
Primary	Allograft survival	defined as re-transplant or initiation of maintenance dialysis	9 years	No
Secondary	cardiovascular event	Acute Myocardial Infarction Revascularization : PCI or CABG Stroke Admission from Congestive heart failure	9 years	No
Secondary	Albuminuria		9 years	No
Secondary	Acute Rejection		9 years	No
Secondary	New onset of diabetes after transplant		9 years	No
Secondary	Quality of Life		2 years	No