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Dietary Oxalate and Innate Immunity in Kidney Stone Disease

Kidney Stone Clinical Trial

Official title:
Dietary Oxalate and Innate Immunity in Kidney Stone Disease

Clinical Trial Summary

This study will test whether oxalate stimulates urinary crystals and impacts the immune system in healthy subjects using two controlled diets (low and high oxalate).

Clinical Trial Description

Oxalate is a small molecule found in plants and plant-derived food. It has been shown that meals containing high amounts of oxalate can increase urinary oxalate excretion, which is a risk factor for calcium oxalate kidney stones (CaOx KS). Small increases in oxalate can stimulate urinary crystals to form which can elicit an immune response. This study consists of having healthy subjects consume both low and oxalate enriched diets to evaluate the effect of oxalate on urinary crystals and immune responses. Participants will receive a low or high oxalate diet for 4 days prior to having a wash out period for 6 days. Participants will then crossover to the opposite oxalate diet for four more days. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04051346
Study type Interventional
Source University of Alabama at Birmingham
Contact
Status Active, not recruiting
Phase N/A
Start date March 5, 2021
Completion date May 1, 2025
View Details
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