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Kidney Stone clinical trials

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NCT ID: NCT06210009 Not yet recruiting - Kidney Stone Clinical Trials

Effect of a DASH-Style Diet on Urinary Risk Factors for Kidney Stone Disease

Start date: May 2024
Phase: N/A
Study type: Interventional

The true capacity for a healthy diet to improve urinary stone risk factors is not well-defined. The objective of this study is to measure the effect of adopting a healthy dietary pattern on kidney stone disease (KSD) risk. The working hypothesis is that a Dietary Approaches to Stop Hypertension (DASH)-style diet will improve 24-hour urine stone risk parameters. The approach to testing this hypothesis will be to randomize participants with KSD to a standardized DASH-style vs. Western-style diet for one week. The Bionutrition Unit of the Center for Clinical and Translational Science will provide all meals to participants. The rationale for this study is that by measuring the effect of a DASH-style diet on urinary stone risk parameters, a benchmark for future real-world, implementation studies will be established. Based on available evidence, this will be the first controlled diet study to assess the DASH dietary pattern for improving urinary stone risk parameters.

NCT ID: NCT06111885 Not yet recruiting - Kidney Stone Clinical Trials

Indapamide and Chlorthalidone to Reduce Urine Supersaturation for Kidney Stone Prevention

INDAPACHLOR
Start date: April 2024
Phase: Phase 2
Study type: Interventional

The aim of this study is to test the efficacy of the two long-acting thiazide-like diuretics indapamide and chlorthalidone in reducing urine supersaturation for calcium oxalate and calcium phosphate compared to the short-acting thiazide diuretic hydrochlorothiazide for the prevention of calcium-containing kidney stones.

NCT ID: NCT05916963 Not yet recruiting - Kidney Stone Clinical Trials

Impact of Forced Diuresis on the Residual Fragment Rate After Flexible Ureteroscopy for Destruction of Kidney Stones With Laser

FIREStones
Start date: December 15, 2023
Phase: Phase 3
Study type: Interventional

In view of the positive results of the numerous studies conducted on forced diuresis after extra-corporeal lithotripsy, the investigators chose to evaluate forced diuresis by injection of Furosemide associated with intravenous hydration, which has never before been the subject of a specific analysis.

NCT ID: NCT05504512 Not yet recruiting - Kidney Diseases Clinical Trials

Percutaneous Nephroscopic Treatment of Parapelvic Cysts

Start date: November 30, 2022
Phase:
Study type: Observational

Background of the project: The surgical treatment of parapelvic cysts is currently less researched and there is no gold standard for surgery. Previously, in percutaneous nephrolithotomy, we found that fenestration and fenestration drainage in the simultaneous treatment of pararenal pelvis cysts under nephroscopic nephroscopic surgery has clear curative effect, less trauma, and quicker recovery. Objective: To clarify the safety, efficacy and long-term efficacy of percutaneous nephroscopy in the treatment of parapelvic cysts. Nature: Retrospective case cohort study. Basic research process: Retrospective collection of cases in our hospital who underwent percutaneous nephroscopy for the treatment of parapelvic cysts, and comparison of preoperative and postoperative cyst size changes and long-term efficacy.

NCT ID: NCT05265936 Not yet recruiting - Kidney Stone Clinical Trials

Is it Safe to Advance a Guidewire Through a Previously Placed Double j Stent?

Start date: March 2022
Phase: N/A
Study type: Interventional

In this prospective randomized controlled study, it is aimed to investigate the effects of guidewire advanced through a previously placed double j stent on postoperative complications, operation time and efficacy.

NCT ID: NCT05213702 Not yet recruiting - Kidney Stone Clinical Trials

A RCT to Evaluate the Efficacy and Safety of Automated Needle Targeting (ANT-X) System Compared to Traditional Free Hand Puncture for Renal Access in Percutaneous Nephrolithotomy (PCNL)

Start date: January 25, 2022
Phase: N/A
Study type: Interventional

Objectives: This study aims to determine if the device provides an advantage over traditional free hand puncture by comparing the number of attempts required to obtain access, time to achieve access, radiation exposure to patient and surgeon; and complications.

NCT ID: NCT05022537 Not yet recruiting - Kidney Stone Clinical Trials

Clinical Outcomes of Percutaneous Nephrolithotomy Following Retrograde Percutaneous Nephrostomy Access Using Novel Device in Comparison to Antegrade Access

Start date: January 2024
Phase: N/A
Study type: Interventional

The purpose of this study is to compare relevant clinical outcomes in patients requiring percutaneous nephrostomy for urolithiasis treatment between those who undergo an antegrade approach versus a retrograde approach and to determine which clinical characteristics predict success of lithotomy with anterograde or retrograde percutaneous nephrostomy approaches.

NCT ID: NCT04651088 Not yet recruiting - Kidney Stone Clinical Trials

Comparing Alkalinizing Agents Efficacy on Stone Risk in Patients on a Metabolically Controlled Diet

Start date: December 2024
Phase: Early Phase 1
Study type: Interventional

The purpose of this study is to compare over the counter and alternative prescription urinary alkalinizing agents to slow release potassium citrate in their ability to modify urinary parameters associated with stone formation.

NCT ID: NCT04606758 Not yet recruiting - Kidney Diseases Clinical Trials

Fluoroscopic Guided vs US-guided Percutaneous Nephrolithotripsy for the Treatment of Stone Disease

Start date: November 2020
Phase: N/A
Study type: Interventional

Randomized comparison of patient outcomes following fluoroscopic guided PCNL versus ultrasound-guided PCNL.

NCT ID: NCT04605055 Not yet recruiting - Kidney Stone Clinical Trials

The Interplay Between Oxalate, Immunity and Infection

Start date: June 1, 2024
Phase: N/A
Study type: Interventional

This study consists of having subjects, those with calcium oxalate kidney stones as well as healthy controls, consume low and oxalate enriched diets to investigate the role of oxalate on crystalluria (the presence of crystals in urine), immunity and infection.