Kidney Cancer Clinical Trial
Official title:
Biological Analysis of Ethnic Variations in Wilms Tumor
RATIONALE: Studying samples of tissue and urine from patients with cancer in the laboratory
may help doctor learn more about changes that occur in DNA and identify biomarkers related
to cancer.
PURPOSE: This research trial studies biomarkers in samples from younger patients with Wilms
tumor.
OBJECTIVES:
- To determine a unique molecular "finger print" of primary Wilms tumor arising in
ethnically diverse children who are at increased risk to develop this lethal malignancy
and subsequently relapse.
- To determine a unique protein "finger print" from the urine of ethnically diverse
children who develop Wilms tumor and subsequent relapse.
OUTLINE: Formalin-fixed paraffin-embedded and snap-frozen primary tissue samples, and urine
samples collected at the time of diagnosis and before treatment, are analyzed for molecular
and protein profile by MALDI-TOF mass spectroscopy, western blotting, immunohistochemistry,
and reverse-transcriptase polymerase chain reaction (RT-PCR) assays.
;
Observational Model: Case-Only, Time Perspective: Retrospective
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