Ketosis Clinical Trial
Official title:
Effects of Exogenous Ketone Ester Supplementation on 3-hydroxybutyrate Concentrations in Human Cerebrospinal Fluid
It is well established that the brain is capable of consuming ketone bodies, especially during low glucose availability, e.g. fasting. Cerebral metabolism of ketone bodies depends on passage of the blood brain barrier and especially the global blood concentration of ketone bodies. Ketone bodies can be administered exogenously, and the most commonly used in clinical trials is 3-hydroxybutyrate (3-OHB). 3-OHB is carried by simple diffusion and facilitated diffusion through several monocarboxylic acid transporters (MCTs) across the blood-brain barrier. To our knowledge, no studies in human adults exist that concurrently measure 3-OHB concentrations in blood and cerebrospinal fluid (CSF) after ingestion or infusion of exogenous ketone supplementation, necessitating further study. Aims: - The 3-OHB CSF/blood ratio after oral ingestion of 30 g ketone ester - primary endpoint - The window of effect: Ketone supplementation 1 h or 2 h before CSF sampling - If concentration measurements by point-of-care testing are non-inferior to mass spectrometry - If acute 3-OHB ingestion increases plasma brain-derived neurotrophic factor (BDNF) levels
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04477161 -
Effect of Ketone Esters in Parkinson's Disease
|
N/A | |
| Active, not recruiting |
NCT05477368 -
Examining the Feasibility of Prolonged Ketone Supplement Drink Consumption in Adults With Type 2 Diabetes
|
N/A | |
| Completed |
NCT04817176 -
MI-CBT Adherence Program for Lifestyle Interventions in Older Adults
|
Early Phase 1 | |
| Completed |
NCT04565444 -
Ketones and Muscle Protein Synthesis
|
N/A | |
| Not yet recruiting |
NCT03954665 -
Ketone Supplementation and Exercise Performance
|
N/A | |
| Active, not recruiting |
NCT06097754 -
Intermittent Exogenous Ketosis (IEK) at High Altitude
|
N/A | |
| Terminated |
NCT03790436 -
Betaquik as an Adjunct to Dietary Management of Epilepsy in Adults on the Modified Atkins Diet
|
N/A | |
| Completed |
NCT03299543 -
Comparison Between Breath Acetone and Blood Beta-Hydroxybutyrate
|
||
| Recruiting |
NCT04004676 -
Ketone Supplementation, Glycogen Replenishment and Time Trial Performance Following Glycogen Lowering Exercise
|
N/A | |
| Not yet recruiting |
NCT03659825 -
Ketone Esters for Optimization of Cognitive Performance in Hypoxia
|
N/A | |
| Active, not recruiting |
NCT04156477 -
Markers of Appetite Regulation During Exogenous Ketosis
|
N/A | |
| Completed |
NCT04130724 -
Characterization of a Portable Solid-State Breath Acetone Testing Device for Real-Time Ketosis Status
|
||
| Recruiting |
NCT04594265 -
Weight-Adjusted Dosing of 3-OHB in Patients With Chronic Heart Failure
|
Phase 2 | |
| Not yet recruiting |
NCT04576026 -
Exogenous Ketone Supplementation and Cognitive Function During Exercise
|
N/A | |
| Completed |
NCT05558488 -
The Effect of a Meatless,Keto Restrictive Diet on Body Composition,Strength Capacity,Oxidative Stress,Immune Response
|
N/A | |
| Recruiting |
NCT03564002 -
Metabolic Effects of Very Low Carbohydrate Ketogenic Diet in Subjects With Severe Obesity
|
||
| Completed |
NCT04309214 -
Market Research - Acceptability Study for New MCT Fat Products
|
N/A | |
| Completed |
NCT05588427 -
Effect of Ketone Ester Supplementation on Hypoxic Tolerance
|
N/A | |
| Recruiting |
NCT05656339 -
Metabolic Effects of Whey Protein Supplementation After Fasting in Volunteers
|
N/A | |
| Active, not recruiting |
NCT04737694 -
Ketone Supplements and Substrate Oxidation and Physical Performance
|
N/A |