The Use of Microneedles to Expedite Treatment Time in Photodynamic Therapy

Status Completed

Clinical Trial Summary

The aim of this study is to investigate how varying incubation periods of topical aminolevulinic acid after pretreatment with microneedle application can facilitate the penetration and efficacy of photodynamic therapy.

Clinical Trial Description

The current standard of care of photodynamic therapy to treat actinic keratoses includes pre-treatment of the area with topical aminolevulinic acid for 1 hour, followed by treatment with blue light. In a previous study, the investigators showed pretreatment of microneedles enhance penetration of topical aminolevulinic acid as compared to the control group.

The aim of this study is to investigate how varying incubation periods of topical aminolevulinic acid after pretreatment with microneedle application can facilitate the penetration and efficacy of photodynamic therapy. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02594644
Study type	Interventional
Source	University of California, Davis
Contact
Status	Completed
Phase	N/A
Start date	November 6, 2014
Completion date	June 22, 2016

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT03076892` - Evaluation of Non-inferiority and Tolerability of the Device PHOS-ISTOS	N/A
Terminated	`NCT03076918` - Evaluating the Device FLEXITHERALIGHT Compared to the Conventional Photodynamic Therapy	N/A
Completed	`NCT05356572` - A Pre-market Study to Evaluate the Performance and Safety of a Skin Preparation Device for Removal of Dry Crusty Skin	N/A
Recruiting	`NCT05387525` - A Study of Tirbanibulin Ointment and Diclofenac Sodium Gel for the Treatment of Adult Participants With Actinic Keratosis on the Face or Scalp	Phase 4
Active, not recruiting	`NCT02281682` - IM Versus 5-FU Versus IMI Versus MAL-PDT in Treatment of Actinic Keratosis	Phase 4
Completed	`NCT01458587` - Levulan PDT Versus Vehicle for Extremity Actinic Keratoses (AK)	Phase 2
Completed	`NCT05260073` - Patient and Clinician Reported Outcomes for Tirbanibulin Effectiveness and Safety in Actinic Keratosis
Active, not recruiting	`NCT06014697` - OCT and Invasion in Cutaneous Skin Lesions
Completed	`NCT05279131` - A Study to Evaluate the Safety and Tolerability of Tirbanibulin Ointment 1% in Adult Participants With Actinic Keratosis	Phase 3
Completed	`NCT05481073` - UV Sensor in Patients With Actinic Keratosis
Completed	`NCT03697590` - Photodynamic Therapy of Actinic Keratosis of the Face and Scalp With and Without Prior Curettage	Phase 4
Withdrawn	`NCT02813902` - A Trial of Polypodium Leucotomos in Preventing Skin Cancer and Its Precursors	Phase 1
Recruiting	`NCT05636800` - Microwave Treatment for Actinic Keratosis	N/A
Completed	`NCT02628236` - Maximal Use Systemic Exposure Study of Levulan Kerastick (MUSE 2)	Phase 2
Recruiting	`NCT06135415` - A Study to Evaluate the Efficacy and Safety of Tirbanibulin Ointment in Adult Participants With Actinic Keratosis	Phase 3
Completed	`NCT02644187` - Pain Relief During Photodynamic Therapy for Actinic Keratoses With a New Irradiation Protocol	N/A
Completed	`NCT02281136` - MUSE Study of Levulan Kerastick	Phase 2
Completed	`NCT05060237` - Study to Evaluate Safety and Tolerability of BF-200 ALA (Ameluz®) for Photodynamic Therapy in the Treatment of the Expanded Field of Actinic Keratosis on Face and Scalp	Phase 1
Terminated	`NCT04269395` - A Study to Assess Recurrence of Actinic Keratosis in Participants Treated With Methyl Aminolevulinate Hydrochloride Cream or Vehicle Cream Who Achieved Complete Response to Treated Lesions in Earlier Study	Phase 3