Ischemic Stroke Clinical Trial
Official title:
Procedural Motor Memory in Long COVID-19
Background: Most people who get COVID-19 seem to recover with no long-term effects. However, some people who recover from acute COVID-19 infections report lingering symptoms. This is called long COVID. Many people with long COVID report symptoms related to the nervous system; these can include problems with fatigue, speech, and memory. Objective: To test motor memory in people with long COVID, compared to healthy volunteers. Eligibility: People aged 18 to 90 years who are also enrolled in study protocol 000089. Healthy adults are also needed. Design: Participants will be screened by telephone. They will confirm they are able to type without discomfort using their nondominant hand. They will confirm they have access to a computer connected to the internet. All study tasks will be done online. Participants will complete 2 tasks in 2 days. Participants will be sent a link to a website. The website will give them instructions. They will place the fingers of their nondominant hand over 4 numbers on the keyboard and type a sequence (eg, 4-1-3-2-4). They will type this sequence as often as they can in 10 seconds. Then they will rest for 10 seconds before repeating the task. They will repeat this pattern for 15 minutes. After they finish the typing task, participants will take a 10-minute questionnaire. They will answer questions about their experiences with COVID-19 and memory issues; they will say which hand they use for tasks such as brushing their teeth or throwing a ball. Participants will get a notice to repeat the typing task 22 hours after they finish the first one. They should complete the second task within 28 hours....
Status | Recruiting |
Enrollment | 1000 |
Est. completion date | June 30, 2025 |
Est. primary completion date | December 31, 2024 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 90 Years |
Eligibility | - INCLUSION CRITERIA: In order to be eligible to participate in this study, patient volunteers must meet all of the following criteria: Ability of subject to understand and the willingness to review an informed consent Aged at least 18 years at the time of enrollment, and no older than 90 years of age. Identity of dominant hand 1. Question: Which hand would you choose to hold the pen to write a formal letter? 2. Note: no specific answer is required for inclusion, but it is required for the next question. English-Speaking: Ability to type without discomfort using non-dominant hand Enrolled in the screening phase of Protocol 000089 Post-Coronavirus Disease 19 Convalescence at the National Institutes of Health in the post-COVID convalescence arm (i.e. reports having started recovery from an acute COVID- 19 infection within past six month and is able to provide documentation of a positive COVID-19 PCR or antibody test) In order to be eligible to participate in this study, healthy volunteers must meet all of the following criteria: Ability of subject to understand and the willingness to review an acknowledgement of participation agreement Aged at least 18 years at the time of enrollment, and no older than 90 years of age English-speaking Ability to identify dominant hand 1. Question: Which hand would you choose to hold the pen to write a formal letter? 2. Note: no specific answer is required for inclusion, but it is required for the next question. Ability to type without discomfort using non-dominant hand Deny active infection with COVID-19, or ongoing symptoms following COVID-19 infection Ability to use an internet-connected laptop or desktop computer in a private setting located in the continental U.S. to complete the study task. This protocol can enroll NIH Employees/staff, including NINDS employees/staff. Staff members from our section and their immediate family members are excluded from participation. EXCLUSION CRITERIA: Patient group: A patient who meets any of the following criteria will be excluded from participation in this study: A condition prior to the diagnosis of COVID-19 infection that would significantly confound interpretation of the behavioral task, as determined by the screening clinician (e.g., prior diagnosis of a neurologic condition such as large stroke, Alzheimer s disease or Parkinson s disease, or severe psychiatric condition). Staff from our section, and their immediate family members Healthy Volunteer group: A person who meets any of the following criteria will be excluded from participation in this study: A condition that would significantly confound interpretation of the research tests as determined by the screening clinician (e.g., prior diagnosis of a neurologic condition such as large stroke, Alzheimer s disease or Parkinson s disease, or severe psychiatric condition) Fever, respiratory symptoms or diagnosis of COVID-19 in the last 14 days. History of COVID-19 with residual neurologic symptoms following diagnosis that did not resolve within 14 days of disease onset. Previous participation in this study (platform filter). |
Country | Name | City | State |
---|---|---|---|
United States | National Institute of Neurological Disorders and Stroke (NINDS) | Bethesda | Maryland |
Lead Sponsor | Collaborator |
---|---|
National Institute of Neurological Disorders and Stroke (NINDS) |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | To investigate differences in procedural memory formation and consolidation during a keyboard typing task between o patients withpersistent symptoms following COVID- 19 infection ( long COVID )and matched controls who deny symptoms of ... | Early procedural motor memory learning will be measuredby the difference in keypress speed between the first training trial and last correct training trial of the Day 1 typing task. | anticipated to complete data analysis by December 2023 |
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