Clinical Trials Logo
  1. Home
  2. Ischemic Reperfusion Injury
  3. NCT05661227

Mechanism of Cardiac and Cerebral Function Injury Caused by Intraoperative Limb Ischemia-reperfusion

Ischemic Reperfusion Injury Clinical Trial

Official title:
Mechanism of Cardiac and Cerebral Function Injury in Patients With Coronary Heart Disease Caused by Intraoperative Limb Ischemia-reperfusion and Perioperative Organ Function Protection Strategy

Clinical Trial Summary

As a simple auxiliary tool for lower extremity orthopedic surgery, tourniquet can effectively reduce intraoperative bleeding and ensure the clarity of the operative field, effectively shorten the operation time and improve the operation efficiency. The extensive use of tourniquets in lower extremity surgery will not only cause local paralysis, pain and other complications, but also bring about postoperative complications such as large drainage volume and deep vein thrombosis. Recent studies have found that tourniquet induced ischemia-reperfusion injury not only affects the local tissue structure and function of skeletal muscle, but also causes reperfusion injury in distant organs (such as heart, lung and brain). Therefore, improving tourniquet ischemia-reperfusion injury after knee replacement is of great significance to improve the quality of life of patients during the perioperative period. Therefore, the aim of this study was to investigate the effects of dexmedetomidine and tourniquet pretreatment on myocardial injury and brain injury caused by lower extremity ischemia-reperfusion.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05661227
Study type Interventional
Source Hebei Medical University Third Hospital
Contact Xin Liu
Phone 18810525281
Email 1536149525@qq.com
Status Recruiting
Phase N/A
Start date January 1, 2023
Completion date June 30, 2024
View Details
See also
  Status Clinical Trial Phase
Completed NCT02134314 - C1INH Inhibitor Preoperative and Post Kidney Transplant to Prevent DGF & IRI Phase 1/Phase 2
Recruiting NCT01476969 - Effect of Remote Ischemic Perconditioning on Acute Kidney Injury in Adult Valve Replace N/A
Completed NCT03050489 - Assessment of Myocardial Ischemic-Reperfusion Injury During Off- and On- Pump CABG
Recruiting NCT02940600 - Efficacy Evaluation of Normothermic Perfusion Machine Preservation in Liver Transplant Using Very Old Donors N/A
Recruiting NCT02649309 - Single-cycle Remote Ischemic Preconditioning and Postconditioning (SCRIP) Trial N/A
Recruiting NCT02729155 - Single-cycle Remote Ischemic Preconditioning and Postconditioning for Prevention of Contrast-Induced Nephropathy N/A
Completed NCT02290080 - Determination of the Role of Oxygen in Suspected Acute Myocardial Infarction by Biomarkers Phase 3
Not yet recruiting NCT04068116 - Impact of Ischemic Post-conditioning N/A
Terminated NCT01726465 - Methylprednisolone N Acetylcysteine in Hepatic Resections Phase 2
Completed NCT03535623 - RIPC During Free Flap With Preoperative Radiotherapy N/A
Completed NCT02581618 - Remote Ischemic Preconditioning in Elective Percutaneous Interventions N/A
Recruiting NCT04000334 - Early Transcranial Doppler Goal Directed Therapy After Cardiac Arrest: a Pilot Study N/A
Completed NCT01887171 - Evaluation of Preimplantation Portal Vein and Hepatic Artery Flushing With Tacrolimus N/A
Recruiting NCT05148715 - Calcineurin Inhibitor in NEuRoloGically Deceased Donors to Decrease Kidney delaYed Graft Function (CINERGY) Phase 2
Completed NCT04257240 - Recurrence of Liver Malignancy After Ischemia/Reperfusion Injury
Active, not recruiting NCT05708053 - Cardio-protective Effect of Metformin in Patients Undergoing PCI Phase 3
Completed NCT05194306 - PERTRIAL - Perla® Preservation Solution N/A
Recruiting NCT05179434 - A Study of Retrograde Reperfusion of Renal Graft to Reduce Ischemic-reperfusion Injury N/A
Not yet recruiting NCT04951791 - Lipid Emulsion in Cardiac Valve Replacement Surgery N/A
Completed NCT01666587 - Ischemia Reperfusion: Prostaglandins and Antioxidants N/A