Ischemia Reperfusion: Prostaglandins and Antioxidants

Ischemic Reperfusion Injury Clinical Trial

Official title:

The Role of Prostaglandin and Anti-oxidant Availability on Recovery From Forearm Ischemia-reperfusion Injury in Humans

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01666587
• Other study ID #: IRAPC
• Secondary ID: DBD0300
• Status: Completed
• Phase: N/A
• First received: August 9, 2012
• Last updated: May 10, 2017
• Start date: August 2012
• Est. completion date: August 2013

Study information

• Verified date: May 2017
• Source: University of Essex
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purposes of this study are two-fold. The first purpose is to determine the effect of taking vitamins on the recovery of an artery (blood vessel) following an induced temporary injury. The second purpose is to determine whether a specific vasodilator is less abundant after the injury and whether this contributes to increased constriction or after the injury. Finally, does vitamin consumption have an effect on the recovery from the injury if one of the substances in the blood that causes vessels to enlarge (dilate) is stopped?

Recruitment information / eligibility

• Status: Completed
• Enrollment: 12
• Est. completion date: August 2013
• Est. primary completion date: April 2013
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 45 Years

Eligibility

Inclusion Criteria:

• Healthy males

• Healthy females

Exclusion Criteria:

• Smokers

• Cardiovascular disease

• Peripheral vascular disease

• Neurological deficits

• Diabetes Type I or II

• Pregnant women

• Adverse reactions to Ibuprofen

Related Conditions & MeSH terms

• Ischemia
• Ischemic Reperfusion Injury
• Reperfusion Injury

Intervention

Dietary Supplement:
• Antioxidant

Drug:
• Prostaglandin inhibitor (Ibuprophen)

Locations

Country	Name	City	State
United Kingdom	University of Essex	Colchester	Essex

Sponsors (1)

Lead Sponsor	Collaborator
University of Essex

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in flow mediated dilation	Flow mediated dilation is a measure of vascular function and is measured as the outcome before and after an injury to the inner lining of the artery.	Change from baseline at 15 minutes after ischemia-reperfusion injury
Secondary	Change in low flow mediated constriction	low flow mediated constriction is a measure of vascular function and is measured to establish the impact of a vascular injury	Change from baseline at 15 minutes after ischemia-reperfusion injury