Ischemic Preconditioning Clinical Trial
Official title:
The Study of Potency of Cross-preconditioning to Prevent Ischemic-reperfusion Injury for Heart Transplantation Recipient
In recent years, a large number of studies confirmed the protective effect of ischemic
preconditioning on myocardium against ischemia/reperfusion injury, but the clinical data of
the effectiveness of ischemic preconditioning in heart transplantation is still missing.
Inspired by the promising data of ischemic preconditioning from the previous reports, the
investigators firstly introduce a novel method of cross ischemic preconditioning technique to
prevent ischemia/reperfusion injury to heart transplant recipients.
This study will evaluate whether this cross-preconditioning technique would attenuate
ischemia/ reperfusion injury to the heart transplant recipients, reduce Intensive Care
Unit(ICU) and total hospitalization stays and the incidence of cardiovascular adverse events
and improve the long-term survival outcomes.
Patients receiving heart transplantation are randomly assigned into the cross ischemic
preconditioning (CICP) intervention group and the control group. (the Statistical Analysis
System (SAS) software was used to generate a random number table and randomly divided into
two groups). After the establishment of the cardiopulmonary bypass, the ascending aorta of
the CICP group will be crossclamped 2 minutes, separated by a 3-minute rest interval, and
repeated successively on 2 occasions.
The recipients in the control group are to undergo routine cardiopulmonary bypass procedure
of heart transplantation.
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