Determinants of Vasospasm and Delayed Ischemic Deficits in Aneurysmal Subarachnoid Hemorrhage

Ischemia Clinical Trial

Official title:

Hemodynamic and Biochemical Determinants of Vasospasm and Delayed Ischemic Deficits in Aneurysmal Subarachnoid Hemorrhage

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02829398
• Other study ID #: 07 304 02
• Secondary ID: Local Grant
• Status: Completed
• Phase: N/A
• First received: July 4, 2016
• Last updated: May 10, 2017
• Start date: March 2008
• Est. completion date: October 2011

Study information

• Verified date: May 2017
• Source: University Hospital, Toulouse
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The risk of delayed cerebral ischemia (DCI) after subarachnoid hemorrhage (SAH) is associated with large cerebral artery vasospasm, but vasospasm is not a strong predictor for DCI. Assessment of cerebral autoregulation with transcranial Doppler (TCD) may improve the prediction of DCI. The aim of this prospective study was to assess the value of TCD-derived variables to be used alone or in combination for prediction of DCI

Recruitment information / eligibility

• Status: Completed
• Enrollment: 41
• Est. completion date: October 2011
• Est. primary completion date: October 2011
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

Group 1 : • Patients who presented a ruptured aneurysm by aneurysmal subarachnoid hemorrhage (SAH) older than 72 hours. Diagnosis of SAH was confirmed by computed tomography, magnetic resonance imaging (MRI) or lumbar puncture as recommended

• symptomatic aneurysm treated with endovascular,

• Absence of achieving a lumbar puncture,

• Patients affiliated to a social security scheme,

• Patients who have given their free and informed consent and signed the consent or consent of the family.

Group 2 :

healthy volunteers with cerebrospinal fluid sample

Exclusion Criteria:

• Patients with no readable acoustic temporal bone window

• Patients with previous disease that might impair cerebral autoregulation (e.g., carotid stenosis, history of stroke or head injury).

Related Conditions & MeSH terms

• Hemorrhage
• Ischemia
• Subarachnoid Hemorrhage

Intervention

Procedure:
• CerebroSpinal fluid and plasma samples
CerebroSpinal fluid and plasma samples for biological markers

Locations

Country	Name	City	State
France	University Hospital of Toulouse	Toulouse

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Toulouse

Country where clinical trial is conducted

France, 

References & Publications (1)

Calviere L, Nasr N, Arnaud C, Czosnyka M, Viguier A, Tissot B, Sol JC, Larrue V. Prediction of Delayed Cerebral Ischemia After Subarachnoid Hemorrhage Using Cerebral Blood Flow Velocities and Cerebral Autoregulation Assessment. Neurocrit Care. 2015 Oct;23 — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	delayed cerebral ischemia	DCI was confirmed by CT or MR imaging	inclusion