The Effect of Anesthetics Agents on Vascular Injury and Level of Syndecan-1 During Knee Surgery

Ischemia Clinical Trial

Official title:

The Effect of Anesthetics Agents on Vascular Injury and Level of Syndecan-1 During Knee Surgery

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02756715
• Other study ID #: KUH1160100
• Status: Completed
• Phase: N/A
• Start date: May 30, 2016
• Est. completion date: February 27, 2020

Study information

• Verified date: February 2020
• Source: Konkuk University Medical Center
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Ischeic reperfusion injury lead to a cellular dyfunction and increase in soluble glycocalyx of blood flow. syndecan-1 was a marker of glycocalyx.

The purpose of this study is to prove the variation of level of serum syndecan-1 between preoperative and postoperative period.

Description:

The patients were allocated randomly to receive propofol or desflurane. Also, a total of 6ml of blood sample was obtained for total 6 times in consecutive order.

1. Preoperation (immediate before anesthesia induction)

2. Immediate before tourniquet off

3. 5 min after tourniquet off

4. PACU

5. postoperative 6 hours

6. postoperative 24 hours

Serum in blood will be obtained and level of serum cytokine will be evaluated by enzyme-linked immunosorbent assay

Recruitment information / eligibility

• Status: Completed
• Enrollment: 80
• Est. completion date: February 27, 2020
• Est. primary completion date: March 26, 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: 20 Years and older

Eligibility

Inclusion Criteria:

• patients who was planned to undergo knee surgery.

Exclusion Criteria:

• age < 20 years old

• history of previous cancer

• history of previous peripheral vascular disease

• Emergency surgery

Related Conditions & MeSH terms

• Ischemia
• Vascular System Injuries

Intervention

Drug:
• propofol group
Patient will be anesthetized by using propofol infusion during operation.
• Desflurane group
Patient will be anesthetized by using desflurane inhalation during operation.

Locations

Country	Name	City	State
Korea, Republic of	Konkuk University Medical Center	Seoul

Sponsors (1)

Lead Sponsor	Collaborator
Konkuk University Medical Center

Country where clinical trial is conducted

Korea, Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Syndecan-1	change of level of syndecan-1 (scores range from 0 to 100)	Preoperative time, Immediate before tourniquet off,5 min after tourniquet off,PACU, postoperation after 6hours, postoperation after 24hours