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The Effect of Anesthetics Agents on Vascular Injury and Level of Syndecan-1 During Knee Surgery

Ischemia Clinical Trial

Official title:
The Effect of Anesthetics Agents on Vascular Injury and Level of Syndecan-1 During Knee Surgery

Clinical Trial Summary

Ischeic reperfusion injury lead to a cellular dyfunction and increase in soluble glycocalyx of blood flow. syndecan-1 was a marker of glycocalyx.

The purpose of this study is to prove the variation of level of serum syndecan-1 between preoperative and postoperative period.

Clinical Trial Description

The patients were allocated randomly to receive propofol or desflurane. Also, a total of 6ml of blood sample was obtained for total 6 times in consecutive order.

1. Preoperation (immediate before anesthesia induction)

2. Immediate before tourniquet off

3. 5 min after tourniquet off

4. PACU

5. postoperative 6 hours

6. postoperative 24 hours

Serum in blood will be obtained and level of serum cytokine will be evaluated by enzyme-linked immunosorbent assay ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02756715
Study type Interventional
Source Konkuk University Medical Center
Contact
Status Completed
Phase N/A
Start date May 30, 2016
Completion date February 27, 2020
View Details
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