Ischemia Clinical Trial
Apply the LASCA for follow-up the postocclusive microcirculation after strangulation of the gingiva in order to characterize the kinetics of the blood flow changes in human subjects.
During surgical endodontics the cortical bone is exposed by elevating a full- thickness
tissue flap. Cutting across mucosal blood vessels disturbs perfusion and causes ischemia. On
the other hand, preserving sufficient blood flow of the soft tissue segment is important for
the postoperative wound healing. In order to minimize the damage of the microvasculature of
the operated area, the incision should be properly designed.
The investigators will model surgical incisions by strangulation of the gingiva of healthy
human subjects based on the commonly applied endodontic incision such as horizontal, vertical
and papilla base. The primary aim is to determine the effect of a short term disruption of
the blood flow at the respective region on the surrounding area in order to assess the
functionally active collateral circulation. Using Laser Speckle Contrast Analysis (LASCA),
which provides blood perfusion data, the investigators will have the possibility to detect
functional alterations in gingival microcirculation during and after a short term of
strangulation. The secondary aim is to assess the time course of the restoration of the
circulation on the affected area.
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