Ischemia Clinical Trial
Official title:
The Effects of Preconditioning on Intramuscular High-Energy Phosphate Levels During Ischemia
Ischemia reperfusion injury may be reduced by ischemic preconditioning. This projects aims
to show the effects of short and long time ischemic preconditioning (both sequences 3 x 5
minutes) during and after an ischemic period of 20 minutes in healthy subjects by functional
MRI. Ischemia is produces by cuff inflation to a suprasystolic pressure on one tight. Signal
is acquired from calf muscles.
A cross-over design of 4 to 8 study periods is used, 4 different study days with 2 different
MR measurement methods (BOLD imaging and high energy phosphates) are planned.
n/a
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Basic Science
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