Irritable Bowel Syndrome Clinical Trial
Official title:
A Randomized Controlled Clinical Trial to Investigate the Efficacy of Traditionally Fermented Sauerkraut in the Treatment of Irritable Bowel Syndrome
The aim of the present study is to assess the efficacy of traditionally fermented sauerkraut in the treatment of irritable bowel syndrome.
Irritable bowel syndrome (IBS) is a chronic gastrointestinal (GI) disorder that affects
around 11% of the population globally. Several factors have been implicated in the
pathogenesis of IBS, including psychological stress, gastrointestinal motility, and diet .
More recently, it has become clear that the gastrointestinal microbiota may play a critical
role in the pathophysiology of this functional GI condition.
Several studies have shown that an altered gut microbiota profile is present in at least some
subgroups of IBS patients. This may, in part, explain why a proportion of IBS patients have
elevated levels of inflammatory mediators in systemic circulation.
Gut microbiome manipulation, for example through the use of probiotic and prebiotic
supplements, has shown some promise in the treatment of IBS. However, the research in this
area is still in its infancy, and it remains unclear what type of intervention that is the
preferred choice in cases of IBS.
Several studies have investigated how the use of probiotic supplements containing
Bifidobacteria and Lactobacilli affect the clinical outcome of patients with IBS. However, to
date, no studies have assessed whether fermented vegetables, a "natural" source of probiotic
bacteria such as Lactobacillus plantarum, are useful in the treatment of IBS.
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