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Campylobacter Enteritis and Post-Infective Bowel Dysfunction (PI-BD): Role of Antibiotics and Microbiota — CERAMIC  

Irritable Bowel Syndrome Clinical Trial

Official title:
An Observational Study of the Role of Antibiotics, Inflammation and Changes in Microbiota in the Development of Post-infective Bowel Dysfunction Following Infection With Campylobacter Jejuni or Coli

Clinical Trial Summary

The principal research objective is to determine the impact of antibiotic use on the risk of developing long term bowel symptoms after infection with the germ Campylobacter.

Clinical Trial Description

The secondary research objectives are:

- To investigate how the particular strain of the Campylobacter germ that causes the infection, and the strength of the immune response that it stimulates in the bowel, affect the risk of long term bowel symptoms.

- To explore what changes occur after Campylobacter infection in the bacteria that usually live in the large bowel (microbiota) and the chemicals that they produce (short-chain fatty acids) when they digest nutrients. We will look for differences between people who recover fully and people who have long term bowel symptoms. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02040922
Study type Observational
Source University of Nottingham
Contact
Status Active, not recruiting
Phase N/A
Start date January 2013
Completion date June 2017
View Details
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