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NCT01028898 Clinical Trial

Abnormal Expression Proteins, Mitochondrial DNA and miRNA of Irritable Bowel Syndrome

Irritable Bowel Syndrome Clinical Trial

— IBS  

Official title:
Screening and Identification of Abnormal Expression Proteins and miRNA From Colonic Mucosa of Patients With Irritable Bowel Syndrome.

Clinical Trial Details — Status: Active, not recruiting

Administrative data
NCT number NCT01028898
Other study ID # IBS and metabolism
Secondary ID
Status Active, not recruiting
Phase N/A
First received December 8, 2009
Last updated February 10, 2011
Start date January 2006
Est. completion date December 2012

Study information
Verified date December 2006
Source Chinese PLA General Hospital
Contact n/a
Is FDA regulated No
Health authority China: Ethics Committee
Study type Observational

Clinical Trial Summary

In the investigators study, the investigators will focus on the screening of the related proteins and miRNA to IBS in order to reveal the possible clues or molecular mechanism for this disorder.

Description:

For the proteomic procedures, Our study groups extracted proteins from the cecum and sigmoid colon samples and ran on the two-dimensional gel electrophoresis (2-DE). The proteins on 2-DE were visualized by the silver stain, and then gel maps were scanned and analyzed with the Image Master 2D Elite. The obvious abnormal protein spots were identified by the mass spectrometry. Western blot 、 immunohistochemistry 、 mRNA and miRNA were also performed for further verification of the proteins.

Recruitment information / eligibility
Status Active, not recruiting
Enrollment 180
Est. completion date December 2012
Est. primary completion date August 2011
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group 18 Years to 60 Years
Eligibility Inclusion Criteria:

- Patients with symptoms meeting Rome III criteria for diagnosis of IBS-C and IBS-D

Exclusion Criteria:

- Patients with organic illnesses or a history of major abdominal surgery

- Major psychotic episode, mental retardation or dementia

- Pregnant women and lactational women

- Postinfectious IBS, PI-IBS

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Related Conditions & MeSH terms

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
Chinese PLA General Hospital
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